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GFR 抗体 (AA 151-250)

RAPGEF5 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1386172
发货至: 中国
  • 抗原 See all GFR (RAPGEF5) 抗体
    GFR (RAPGEF5) (Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5))
    抗原表位
    • 14
    • 8
    • 7
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 151-250
    适用
    • 49
    • 13
    • 6
    宿主
    • 47
    • 3
    克隆类型
    • 49
    • 1
    多克隆
    标记
    • 15
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This GFR antibody is un-conjugated
    应用范围
    • 37
    • 22
    • 12
    • 12
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    预测反应
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human RAPGEF5
    亚型
    IgG
    Top Product
    Discover our top product RAPGEF5 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    GFR (RAPGEF5) (Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5))
    别名
    RAPGEF5/Repac (RAPGEF5 产品)
    别名
    GFR antibody, MR-GEF antibody, REPAC antibody, 4932413M22 antibody, C86120 antibody, D030051B22Rik antibody, Mrgef antibody, mKIAA0277 antibody, mmr-gef antibody, RGD1562891 antibody, rMR-GEF antibody, MGC154311 antibody, Rap guanine nucleotide exchange factor 5 antibody, Rap guanine nucleotide exchange factor (GEF) 5 antibody, Rap guanine nucleotide exchange factor 5 S homeolog antibody, RAPGEF5 antibody, Rapgef5 antibody, rapgef5.S antibody
    背景

    Synonyms: GFR, Guanine nucleotide exchange factor for Rap1, KIAA0277, M Ras regulated Rap GEF, M-Ras-regulated Rap GEF, MR GEF, MR-GEF, MRGEF, Rap guanine nucleotide exchange factor 5, Rapgef5, Related to Epac, Repac, RPGF5_HUMAN.

    Background: Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.

    途径
    RTK signaling, Neurotrophin Signaling Pathway, Hepatitis C
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