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FOXP3 抗体

FOXP3 适用: 人, 小鼠 WB, FACS 宿主: 小鼠 Monoclonal 3G3 unconjugated
产品编号 ABIN1302424
发货至: 中国
  • 抗原 See all FOXP3 抗体
    FOXP3 (Forkhead Box P3 (FOXP3))
    适用
    • 154
    • 112
    • 46
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    人, 小鼠
    宿主
    • 116
    • 57
    • 11
    • 2
    小鼠
    克隆类型
    • 116
    • 70
    单克隆
    标记
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    This FOXP3 antibody is un-conjugated
    应用范围
    • 132
    • 82
    • 70
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    Western Blotting (WB), Flow Cytometry (FACS)
    特异性
    The mouse monoclonal antibody 3G3 recognizes N-terminal region of FoxP3, a 47-55 kDa transcription factor (intracellular antigen), which is the master regulator in the development and function of regulatory T cells.
    交叉反应 (详细)
    Human, Mouse
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Full-length His-tagged recombinant murine FoxP3
    克隆位点
    3G3
    亚型
    IgG1 kappa
    Top Product
    Discover our top product FOXP3 Primary Antibody
  • 应用备注
    Western blotting: Recommended dilution: 2 μg/mL.
    Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Law, Hirschkorn, Owen, Biswas, Norris, Lanteri: "The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 75, Issue 12, pp. 1040-50, (2009) (PubMed).

    Gavin, Torgerson, Houston, DeRoos, Ho, Stray-Pedersen, Ocheltree, Greenberg, Ochs, Rudensky: "Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 17, pp. 6659-64, (2006) (PubMed).

  • 抗原
    FOXP3 (Forkhead Box P3 (FOXP3))
    别名
    FoxP3 (FOXP3 产品)
    别名
    foxp3 antibody, FOXP3 antibody, AIID antibody, DIETER antibody, IPEX antibody, PIDX antibody, XPID antibody, JM2 antibody, scurfin antibody, sf antibody, RGD1562112 antibody, forkhead box P3 antibody, forkhead box P3a antibody, forkhead box P3 L homeolog antibody, FOXP3 antibody, foxp3a antibody, foxp3 antibody, foxp3.L antibody, Foxp3 antibody
    背景
    Forkhead box P3,FoxP3 (forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.,Scurfin, JM2, AIID, IPEX, PIDX, XPID, DIETER
    基因ID
    50943
    UniProt
    Q9BZS1
    途径
    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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