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TCR beta 抗体

TCR beta 适用: 小鼠 FACS, IP, WB, IHC (fro), IHC (f) 宿主: Armenian Hamster Monoclonal H57-597 unconjugated
产品编号 ABIN1177302
发货至: 中国
  • 抗原 See all TCR beta 抗体
    TCR beta (T Cell Receptor (TCR) beta (TCR beta))
    适用
    • 30
    • 15
    小鼠
    宿主
    • 22
    • 11
    • 8
    • 4
    Armenian Hamster
    克隆类型
    • 34
    • 11
    单克隆
    标记
    • 13
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TCR beta antibody is un-conjugated
    应用范围
    • 34
    • 12
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    品牌
    BD Pharmingen™
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    过滤
    0.2 μm filtered
    内毒素水平
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    免疫原
    TCR affinity-purified from mouse T-cell hybridoma DO-11.10
    克隆位点
    H57-597
    亚型
    IgG2 lambda
    Top Product
    Discover our top product TCR beta Primary Antibody
  • 应用备注
    Flow cytometry: It has been observed that pre-incubation of thymus cell suspensions at 37°C for 2-4 hours prior to staining enhances the ability of anti-CD3e and anti-TCR beta chain mAbs to detect the T cell receptor on immature thymocytes.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.0 mg/mL
    缓冲液
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    储存液
    Azide free
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Saint-Ruf, Panigada, Azogui, Debey, von Boehmer, Grassi: "Different initiation of pre-TCR and gammadeltaTCR signalling." in: Nature, Vol. 406, Issue 6795, pp. 524-7, (2000) (PubMed).

    Vicari, Zlotnik: "Mouse NK1.1+ T cells: a new family of T cells." in: Immunology today, Vol. 17, Issue 2, pp. 71-6, (1996) (PubMed).

    Atsuta, Nishimura, Nakamura, Emoto, Iwatsuki, Yoshikai: "Diversity of V gamma gene segments rearranged to the J gamma 4 gene in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 2, pp. 676-84, (1995) (PubMed).

    Davenport, Kumar, Bennett: "Rapid rejection of H2k and H2k/b bone marrow cell grafts by CD8+ T cells and NK cells in irradiated mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 8, pp. 3742-9, (1995) (PubMed).

    Bendelac, Killeen, Littman, Schwartz: "A subset of CD4+ thymocytes selected by MHC class I molecules." in: Science (New York, N.Y.), Vol. 263, Issue 5154, pp. 1774-8, (1994) (PubMed).

    Ohno, Ono, Hirayama, Shimada, Saito: "Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia." in: The Journal of experimental medicine, Vol. 179, Issue 1, pp. 365-9, (1994) (PubMed).

    Saint-Ruf, Ungewiss, Groettrup, Bruno, Fehling, von Boehmer: "Analysis and expression of a cloned pre-T cell receptor gene." in: Science (New York, N.Y.), Vol. 266, Issue 5188, pp. 1208-12, (1994) (PubMed).

    Groettrup, von Boehmer: "T cell receptor beta chain dimers on immature thymocytes from normal mice." in: European journal of immunology, Vol. 23, Issue 6, pp. 1393-6, (1993) (PubMed).

    Skeen, Ziegler: "Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection." in: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 971-84, (1993) (PubMed).

    Lefrancois: "Phenotypic complexity of intraepithelial lymphocytes of the small intestine." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 6, pp. 1746-51, (1991) (PubMed).

    Bonneville, Itohara, Krecko, Mombaerts, Ishida, Katsuki, Berns, Farr, Janeway, Tonegawa: "Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity." in: The Journal of experimental medicine, Vol. 171, Issue 4, pp. 1015-26, (1990) (PubMed).

    Gascoigne: "Transport and secretion of truncated T cell receptor beta-chain occurs in the absence of association with CD3." in: The Journal of biological chemistry, Vol. 265, Issue 16, pp. 9296-301, (1990) (PubMed).

    Kubo, Born, Kappler, Marrack, Pigeon: "Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 8, pp. 2736-42, (1989) (PubMed).

  • 抗原
    TCR beta (T Cell Receptor (TCR) beta (TCR beta))
    Abstract
    TCR beta 产品
    别名
    TCRbeta antibody, Tib antibody, T cell receptor beta chain antibody, Tcrb antibody
    背景
    The H57-597 antibody reacts with a common epitope of the beta chain of the T-cell Receptor (TCR) complex on alphabeta TCR-expressing thymocytes and peripheral T lymphocytes and NK1.1+ thymocytes and NK-T cells of all mouse strains tested. It does not react with gammadelta TCR-bearing T cells. In the fetal and adult thymus, the TCR beta-chain may form homodimers or pair with the pre-TCR alpha-chain on the surface of immature thymocytes before expression of the TCR alpha-chain. Plate-bound or soluble H57-597 antibody activates alphabeta TCR-bearing T cells, and plate-bound mAb can induce apoptotic death.
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