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MAPKAP Kinase 2 抗体 (pThr334) (Alexa Fluor 488)

MAPKAPK2 适用: 人, 小鼠 ICS 宿主: 小鼠 Monoclonal P24-694 Alexa Fluor 488
产品编号 ABIN1177089
发货至: 中国
  • 抗原 See all MAPKAP Kinase 2 (MAPKAPK2) 抗体
    MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
    抗原表位
    • 35
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    pThr334
    适用
    • 106
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    人, 小鼠
    宿主
    • 134
    • 3
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    小鼠
    克隆类型
    • 120
    • 19
    单克隆
    标记
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    This MAPKAP Kinase 2 antibody is conjugated to Alexa Fluor 488
    应用范围
    • 90
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    Intracellular Staining (ICS)
    品牌
    BD Phosflow™
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Phosphorylated Human MAPKAPK-2 Peptide
    克隆位点
    P24-694
    亚型
    IgG1 kappa
    Top Product
    Discover our top product MAPKAPK2 Primary Antibody
  • 样本量
    5 μL
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated to Alexa Fluor® 488 under optimum conditions, and unreacted Alexa Fluor® 488 was removed.
  • Manke, Nguyen, Lim, Stewart, Elia, Yaffe: "MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation." in: Molecular cell, Vol. 17, Issue 1, pp. 37-48, (2005) (PubMed).

    Wang, Xu, Wang, Young, Gaestel, Feuerstein: "Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 43968-72, (2002) (PubMed).

    Heidenreich, Neininger, Schratt, Zinck, Cahill, Engel, Kotlyarov, Kraft, Kostka, Gaestel, Nordheim: "MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 14434-43, (1999) (PubMed).

    Engel, Kotlyarov, Gaestel: "Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation." in: The EMBO journal, Vol. 17, Issue 12, pp. 3363-71, (1998) (PubMed).

    Krump, Sanghera, Pelech, Furuya, Grinstein: "Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils." in: The Journal of biological chemistry, Vol. 272, Issue 2, pp. 937-44, (1997) (PubMed).

    Ben-Levy, Leighton, Doza, Attwood, Morrice, Marshall, Cohen: "Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2." in: The EMBO journal, Vol. 14, Issue 23, pp. 5920-30, (1996) (PubMed).

    Clifton, Young, Cohen: "A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress." in: FEBS letters, Vol. 392, Issue 3, pp. 209-14, (1996) (PubMed).

    Rouse, Cohen, Trigon, Morange, Alonso-Llamazares, Zamanillo, Hunt, Nebreda: "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins." in: Cell, Vol. 78, Issue 6, pp. 1027-37, (1994) (PubMed).

  • 抗原
    MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
    别名
    MAPKAPK-2 (MAPKAPK2 产品)
    别名
    mapkapk2 antibody, wu:fb30e10 antibody, wu:fc56c10 antibody, wu:fi03a01 antibody, MGC78852 antibody, MAPKAPK2 antibody, AA960234 antibody, MAPKAP-K2 antibody, MK-2 antibody, MK2 antibody, Rps6kc1 antibody, mitogen-activated protein kinase-activated protein kinase 2a antibody, mitogen-activated protein kinase-activated protein kinase 2 L homeolog antibody, mitogen-activated protein kinase-activated protein kinase 2 antibody, MAP kinase-activated protein kinase 2 antibody, mapkapk2a antibody, mapkapk2.L antibody, MAPKAPK2 antibody, Mapkapk2 antibody
    背景
    The P24-694 monoclonal antibody specifically binds to the phosphorylated T334 site (pT334) of MAPKAPK-2. MAPKAPK-2 is a serine/threonine protein kinase. This ~49 kDa member of the MAPKAPK family of protein kinases is also known as mitogen-activated protein kinase-activated protein kinase 2. MAPKAPK-2 is phosphorylated and activated by p38 MAP kinase in response to stress, cytokines and chemokines. MAPKAPK-2 is phosphorylated on multiple sites including Thr222, Ser272 and Thr334. Phosphorylation of any two of these three amino acid residues seems to be required for the activation of this kinase that serves multiple cellular functions. Phosphorylation of Thr334 was reported to be essential for nuclear export of the heterodimer formed between p38 MAPK and MAPKAPK-2. Mice deficient in MAPKAPK-2 have been shown to be protected from ischemic injury. MAPKAPK-2 is also reported to serve as a cell cycle checkpoint kinase in response to UV irradiation. The heat shock protein, HSP27 was shown to be one of the major substrates of MAPK and MAPKAPK-2.
    Synonyms: MAP kinase-activated protein kinase 2, MAPKAP kinase 2, MK2, MAPK2
    途径
    MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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