(1 reference)-
- 抗原 See all LCP2 抗体
- LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This LCP2 antibody is conjugated to PE
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应用范围
- Intracellular Staining (ICS)
- 品牌
- BD Phosflow™
- 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human SLP-76 SH2 domain Recombinant Protein
- 克隆位点
- H3
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product LCP2 Primary Antibody
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anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 202-463) antibody
LCP2 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (N-Term) antibodyVerified LCP2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 216-434) antibodyLCP2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 284-533) antibodyLCP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 94-143), (pTyr128) antibodyLCP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (pTyr128) antibodyLCP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 46-80) antibodyLCP2 适用: 人 WB 宿主: 兔 Polyclonal RB56244 unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 303-337) antibodyLCP2 适用: 人 WB 宿主: 兔 Polyclonal RB56245 unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 216-434) antibodyLCP2 适用: 人 WB, IP, FACS 宿主: 小鼠 Monoclonal H76 unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) antibodyLCP2 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
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- 样本量
- 20 μL
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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: "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function." in: The Journal of biological chemistry, Vol. 271, Issue 33, pp. 19641-4, (1996) (PubMed).
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: "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function." in: The Journal of biological chemistry, Vol. 271, Issue 33, pp. 19641-4, (1996) (PubMed).
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- 抗原
- LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))
- 别名
- SLP-76 (LCP2 产品)
- 别名
- AI323664 antibody, BB161688 antibody, SLP-76 antibody, SLP76 antibody, twm antibody, Slp76 antibody, lymphocyte cytosolic protein 2 antibody, Lcp2 antibody, LCP2 antibody
- 背景
- SLP-76 (SH2 domain-containing Leukocyte Protein of 76 kDa) is a tyrosine phosphoprotein that is involved in the T cell receptor (TCR) -mediated intracellular signaling pathway. It may be involved in the signaling pathways of other peripheral blood leukocytes, thymic/splenic cells, and in human T, B, and monocytic cell lines. SLP-76 consists of several motifs that signify its importance in protein-protein interactions involved in intracellular signaling pathways, such as the SH2 domain in the C-terminus, the three amino-terminus 17-amino acid repeats with conserved tyrosine and acidic residues (DYE(S/P)P), and a proline rich region. SLP-76 has been shown to associate with Gads, Grb2, PLCg1, SLAP-130, and Vav, all of which are part of the signaling cascade in T lymphocytes. An early event in the T cell activation pathway is the phosphorylation, by the Syk-family kinase ZAP-70, of SLP-76 at the three conserved tyrosine motifs, which then mediate interactions with downstream effectors. The H3 monoclonal antibody recognizes SLP-76, regardless of phosphorylation status. This antibody conjugate is routinely tested by intracellular flow cytometry.
- 途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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