FOXP3 抗体 (Forkhead Box P3)

Details for Product anti-FOXP3 Antibody No. ABIN1169339
抗原
适用
小鼠
181
107
46
19
9
4
3
2
2
1
1
1
1
宿主
大鼠
112
83
14
9
2
克隆类型 (克隆位点)
单克隆 ()
标记
This FOXP3 antibody is un-conjugated
20
13
12
12
8
8
2
2
2
2
2
2
2
2
2
2
2
2
2
2
应用范围
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
138
98
96
64
52
21
17
17
15
14
9
5
4
3
3
2
选项
免疫原 Recombinant mouse FOXP3.
克隆位点 MF333F
亚型 IgG2a
特异性 Recognizes mouse FOXP3. Detects a band of ~46-49 kDa by Western blot.
交叉反应 小鼠
过滤 0.2 μm filtered
抗原
别名 FOXP3 (FOXP3 Antibody 摘要)
背景 FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.
UniProt Q99JB6
途径 Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Liquid
浓度 1 mg/mL
缓冲液 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
储存液 Without preservative
储存条件 4 °C,-20 °C
储存方法 Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
有效期 12 months
厂商提供的图像
Image no. 1 for anti-Forkhead Box P3 (FOXP3) antibody (ABIN1169339) Immunofluorescent imaging of activated mouse CD4+ T cells with anti-FOXP3 (mouse), mA...
Image no. 2 for anti-Forkhead Box P3 (FOXP3) antibody (ABIN1169339) Western blot analysis of mouse Foxp3 using anti-Foxp3 (mouse), mAb(MF333F) at 1:2,0...
有引用在: Perone, Bertera, Shufesky, Divito, Montecalvo, Mathers, Larregina, Pang, Seth, Wucherpfennig, Trucco, Baum, Morelli: "Suppression of autoimmune diabetes by soluble galectin-1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 5, pp. 2641-53, 2009 (PubMed).

Nanni, Nicoletti, Palladini, Croci, Murgo, Antognoli, Landuzzi, Fabbi, Ferrini, Musiani, Iezzi, De Giovanni, Lollini: "Antimetastatic activity of a preventive cancer vaccine." in: Cancer research, Vol. 67, Issue 22, pp. 11037-44, 2007 (PubMed).

Turnquist, Raimondi, Zahorchak, Fischer, Wang, Thomson: "Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 11, pp. 7018-31, 2007 (PubMed).

Lan, Wang, Raimondi, Wu, Colvin, de Creus, Thomson: ""Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 9, pp. 5868-77, 2006 (PubMed).

Perone, Bertera, Tawadrous, Shufesky, Piganelli, Baum, Trucco, Morelli: "Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 8, pp. 5278-89, 2006 (PubMed).

Ambrosino, Spadaro, Iezzi, Curcio, Forni, Musiani, Wei, Cavallo: "Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance." in: Cancer research, Vol. 66, Issue 15, pp. 7734-40, 2006 (PubMed).

Raimondi, Shufesky, Tokita, Morelli, Thomson: "Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 5, pp. 2808-16, 2006 (PubMed).