TNFRSF10B 抗体
(7 references)-
- 抗原 See all TNFRSF10B 抗体
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TNFRSF10B antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Functional Studies (Func)
- 特异性
- Recognizes human TRAIL-R2.
- 交叉反应
- 人
- 交叉反应 （详细）
- Does not cross-react with human TRAIL-R1, -R3 or -R4.
- 纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
- 纯度
- >95 % (SDS-PAGE)
- 免疫原
- Recombinant human TRAIL-R2 (DR5).
- 克隆位点
- HS201
- 亚型
- IgG1
- Top Product
- Discover our top product TNFRSF10B Primary Antibody
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 234-435) antibody
TNFRSF10B 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 233-440) antibodyTNFRSF10B 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 1-440) antibodyTNFRSF10B 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 266-393) antibodyTNFRSF10B 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal DR5-3381 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 71-170) antibodyTNFRSF10B 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2D6 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (N-Term) antibodyTNFRSF10B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-210) antibodyTNFRSF10B 适用: 人 WB, FACS, ELISA, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 2H5B8 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 301-381) antibodyTNFRSF10B 适用: 人 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibodyTNFRSF10B 适用: 人, 小鼠 WB, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-186) antibodyTNFRSF10B 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM113 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - 有效期
- 12 months
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: "The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2." in: Molecular cell, Vol. 65, Issue 4, pp. 730-742.e5, (2017) (PubMed).
: "Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs." in: Cell death and differentiation, Vol. 11 Suppl 1, pp. S86-96, (2004) (PubMed).
: "Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5." in: The Journal of biological chemistry, Vol. 279, Issue 53, pp. 55594-601, (2004) (PubMed).
: "TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 4, pp. 1814-21, (2003) (PubMed).
: "Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation." in: Molecular and cellular biology, Vol. 23, Issue 3, pp. 777-90, (2003) (PubMed).
: "Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8." in: The EMBO journal, Vol. 21, Issue 17, pp. 4520-30, (2002) (PubMed).
: "Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 454-61, (2002) (PubMed).
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: "The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2." in: Molecular cell, Vol. 65, Issue 4, pp. 730-742.e5, (2017) (PubMed).
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- 抗原
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
- 别名
- TRAIL-R2 (TNFRSF10B 产品)
- 别名
- TNFRSF10B antibody, dr5 antibody, cd262 antibody, killer antibody, trick2 antibody, trickb antibody, xDR-M1 antibody, xDR-M2 antibody, ztnfr9 antibody, trailr2 antibody, trick2a antibody, trick2b antibody, CD262 antibody, DR5 antibody, KILLER antibody, KILLER/DR5 antibody, TRAIL-R2 antibody, TRAILR2 antibody, TRICK2 antibody, TRICK2A antibody, TRICK2B antibody, TRICKB antibody, ZTNFR9 antibody, Ly98 antibody, MK antibody, tumor necrosis factor receptor superfamily, member 10b antibody, tumor necrosis factor receptor superfamily member 10b S homeolog antibody, tumor necrosis factor receptor superfamily member 10b L homeolog antibody, tumor necrosis factor receptor superfamily member 10b antibody, TNF receptor superfamily member 10b antibody, Tnfrsf10b antibody, TNFRSF10B antibody, tnfrsf10b.S antibody, tnfrsf10b.L antibody, tnfrsf10b antibody
- 背景
- TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
- UniProt
- O14763
- 途径
- p53 Pathway, Apoptosis, Positive Regulation of Endopeptidase Activity
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