Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
特异性
This antibody detects ATPase subunit F6 (mid region).
交叉反应 (详细)
Species reactivity (tested):Human, mouse, rat
纯化方法
Immunogen affinity purified
免疫原
A synthetic peptide mapping at the middle region of human mature ATP5J (CF6) .Remarks: Sequence is different from the related mouse sequence by two amino acids.
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 (ATP5J) is a multisubunit membrane-bound enzyme complex consisting of an F0 segment embedded in the membrane and an F1 segment attached to the F0. It is also a component of mitochondrial ATP synthase which is required for the interactions of the catalytic and proton-translocating segments. Human ATP5J shares 72 % sequence identity with rat ATP5J.This import signal peptide is rich in basic amino acids, devoid of acidic amino acids, and amphiphilic, which allows it to be water-soluble yet capable of passage through the phospholipid membrane bilayers. Moreover, it is circulating and functions as an endogenous vasoconstrictor by inhibiting cytosolic phospholipase A2.Synonyms: ATP synthase, ATP synthase-coupling factor 6 mitochondrial, ATP5A, ATP5J, ATPM, Complex V subunit F6, F1F0 ATPase subunit F6, H+ transporting, mitochondrial F0 complex, subunit F6