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ING4 抗体 (Isoform 1)

ING4 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN105223
发货至: 中国
  • 抗原 See all ING4 抗体
    ING4 (Inhibitor of Growth Family, Member 4 (ING4))
    抗原表位
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 164-175, Isoform 1
    适用
    • 29
    • 16
    • 13
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 26
    • 3
    山羊
    克隆类型
    • 28
    • 1
    多克隆
    标记
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ING4 antibody is un-conjugated
    应用范围
    • 17
    • 12
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    产品特性
    Concentration Definition: by UV absorbance at 280 nm
    免疫原
    This affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 164-175 of Human p29 ING4 protein (Inhibitor of growth family, member 4). This sequence only shows homology to for ING4.
    亚型
    IgG
    Top Product
    Discover our top product ING4 Primary Antibody
  • 应用备注
    This affinity-purified antibody has been tested for use in ELISA against the immunizing peptide.  Specific conditions for western blotting reactivity should be optimized by the end user.  Expect a band at approximately 29 kDa in size corresponding to ING4 isoform 1 by western blotting in the appropriate cell lysate or extract.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.28 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • Colla, Tagliaferri, Morandi, Lunghi, Donofrio, Martorana, Mancini, Lazzaretti, Mazzera, Ravanetti, Bonomini, Ferrari, Miranda, Ladetto, Neri, Neri, Greco, Mangoni, Bonati, Rizzoli, Giuliani et al.: "The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha ..." in: Blood, Vol. 110, Issue 13, pp. 4464-75, (2007) (PubMed).

    Unoki, Shen, Zheng, Harris: "Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34677-86, (2006) (PubMed).

  • 抗原
    ING4 (Inhibitor of Growth Family, Member 4 (ING4))
    别名
    p29 ING4 (ING4 产品)
    别名
    wu:fb11d09 antibody, wu:fb50e02 antibody, zgc:110619 antibody, ING4 antibody, my036 antibody, p29ING4 antibody, D6Wsu147e antibody, D6Xrf92 antibody, inhibitor of growth family, member 4 antibody, inhibitor of growth family member 4 antibody, ing4 antibody, ING4 antibody, Ing4 antibody
    背景
    P29 ING4 is a tumor suppressor protein similar to ING1 that  may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. p29 ING4 has been shown to suppress brain tumor angio-genesis through transcriptional repression of RelA/ NFKB3 target genes when complexed with RelA.  p29 ING4 may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. p29 ING4 shows a nuclear localization and interacts with EP300, TP53, RelA, inhibits cell growth, and induces apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Multiple alternatively spliced transcript variants have been observed.  The accession number listed below is for variant (1) that encodes the longest isoform.
    Synonyms: NG-4 antibody, ING1 like protein antibody, Inhibitor of growth family member 4 antibody, Inhibitor of growth family member 4 long isoform antibody, Inhibitor of growth protein 4 antibody, MGC12557 antibody
    基因ID
    51147
    UniProt
    Q9UNL4
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