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TIMP4 抗体

TIMP4 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 9:4-7 unconjugated
产品编号 ABIN1043744
发货至: 中国
  • 抗原 See all TIMP4 抗体
    TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))
    适用
    • 70
    • 37
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    • 1
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    人, 小鼠
    宿主
    • 87
    • 12
    小鼠
    克隆类型
    • 87
    • 12
    单克隆
    标记
    • 39
    • 17
    • 10
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    • 2
    • 2
    • 2
    • 2
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    • 2
    • 2
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    • 1
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    This TIMP4 antibody is un-conjugated
    应用范围
    • 79
    • 46
    • 40
    • 13
    • 13
    • 11
    • 9
    • 8
    • 8
    • 7
    • 6
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    特异性
    Anti-TIMP4 was purified from clarified mouse ascetic fluid by Protein A chromatography followed by extensive dialysis against the buffer stated above. TIMP4 antibody is specific for human TIMP4 protein. This antibody reacts with human TIMP4 in tissue sections of formalin-fixed, paraffin-embedded In ELISAs and Native-PAGE, this antibody does not cross-react with recombinant human TIMP-1, -2 or -3. A BLAST analysis was used to suggest cross-reactivity with TIMP4 from human and mouse sources based on the immunizing sequence. Cross-reactivity with TIMP-4 from other sources has not been determined.
    产品特性
    Tissue inhibitor of metalloproteinase-4 (TIMP-4) is member of the TIMP family of inhibitors of matrix metalloproteinase (MMP) activities. In addition, TIMPs have non-MMP associated functions, including roles in growth promotion, apoptosis, and angiogenesis. All four members of the TIMP gene family form a similar secondary structure due to the formation of six highly conserved disulfide bonds. It has been reported that some TIMPs, TIMP4 included, can bind a tetraspanin in the plasma membrane, initiating an intra-cellular signaling cascade. Elevated levels of TIMP4 have been associated with breast cancer progression and heart disease.
    过滤
    Sterile filtered
    免疫原
    Anti-TIMP4 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with full legnth human TIMP4 protein followed by hybridoma development.
    Immunogen Type: RecombinantProtein
    克隆位点
    9:4-7
    亚型
    IgG2b kappa
    Top Product
    Discover our top product TIMP4 Primary Antibody
  • 应用备注
    Anti-TIMP4 antibody has been tested for use in ELISA, Native - Western, and IHC (P). SDS-PAGE - Western Blot not useful for endogenous detection. Specific conditions for reactivity should be optimized by the end user.
    说明

    Gene Name: TIMP4

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.0 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    有效期
    12 months
  • Donover, Wojciechowski, Thirumaran, Zemba-Palko, Prendergast, Wallon: "Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissues." in: Journal of cellular biochemistry, Vol. 110, Issue 5, pp. 1255-61, (2010) (PubMed).

  • 抗原
    TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))
    别名
    TIMP4 (TIMP4 产品)
    别名
    TIMP4 antibody, TIMP-4 antibody, timp4 antibody, TIMP metallopeptidase inhibitor 4 antibody, TIMP metallopeptidase inhibitor 4, tandem duplicate 3 antibody, tissue inhibitor of metalloproteinase 4 antibody, TIMP4 antibody, timp4.3 antibody, Timp4 antibody
    背景
    Tissue inhibitor of metalloproteinase-4 (TIMP-4) is member of the TIMP family of inhibitors of matrix metalloproteinase (MMP) activities. In addition, TIMPs have non-MMP associated functions, including roles in growth promotion, apoptosis, and angiogenesis. All four members of the TIMP gene family form a similar secondary structure due to the formation of six highly conserved disulfide bonds. It has been reported that some TIMPs, TIMP4 included, can bind a tetraspanin in the plasma membrane, initiating an intra-cellular signaling cascade. Elevated levels of TIMP4 have been associated with breast cancer progression and heart disease.
    Synonyms: Tissue inhibitor of metalloproteinase-4, Metalloproteinase inhibitor 4, TIMP-4, TIMP 4, TIMP4 antibody, anti-TIMP4 antibody
    基因ID
    7079
    NCBI登录号
    NM_003256
    UniProt
    Q99727
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