Kinesin Family Member 5A (KIF5A) (C-Term) 抗体

ABIN1002704 产品详细信息
抗原
  • KIF5A
  • kif5a
  • si:ch211-166e11.4
  • wu:fj61a10
  • nkhc
  • my050
  • spg10
  • d12s1889
  • MGC122802
  • D12S1889
  • MY050
  • NKHC
  • SPG10
  • D10Bwg0738e
  • Khc
  • Kif5
  • Kns
  • mKIAA4086
  • kinesin family member 5A
  • kinesin family member 5A, a
  • KIF5A
  • kif5aa
  • kif5a
  • Kif5a
抗原表位
C-Term
17
6
6
4
3
3
3
1
1
1
1
适用
人, 小鼠, 大鼠
56
35
28
5
4
3
3
3
2
1
1
1
1
1
1
宿主

54
14
1
克隆类型
多克隆
标记
非结合性
3
3
1
1
1
1
应用范围
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
55
34
24
11
7
6
5
5
5
3
2
选项
免疫原 KIF5 antibody was raised in rabbits against a 20 amino acid peptide from near the carboxy terminus of human KIF5.
Blocking Peptide Blocking peptide for this product available: ABIN1003811
亚型 IgG
纯化方法 Affinity chromatography purified via peptide column.
抗原
别名 KIF5 (KIF5A Antibody 摘要)
背景 The kinesin superfamily proteins (KIFs) are microtubule-dependent motors that slide along microtubules and transport cellular organelles and mRNA to different parts of the cell. In neurons, KIF5 performs this role in an anterograde fashion from the neuronal cell body to axonal or dendritic terminals. KIF5 was initially differentiated from the ubiquitously expressed kinesin as being highly enriched in subsets of neurons and selectively concentrated in the cell body. KIF5 has at least three known isoforms, this antibody recognizes all three. Mutations in one of the isoforms of KIF5 (KIF5A) are thought to be involved in hereditary spastic paraplegias.
应用备注 KIF5 antibody can be used for detection of KIF5 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
限制 仅限研究用
状态 Liquid
缓冲液 Antibody is supplied in PBS containing 0.02% sodium azide.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
储存条件 4 °C
有效期 12 months
有引用在: Hirokawa: "mRNA transport in dendrites: RNA granules, motors, and tracks." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 27, pp. 7139-42, 2006 (PubMed).

Fichera, Lo Giudice, Falco, Sturnio, Amata, Calabrese, Bigoni, Calzolari, Neri: "Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia." in: Neurology, Vol. 63, Issue 6, pp. 1108-10, 2004 (PubMed).

Niclas, Navone, Hom-Booher, Vale: "Cloning and localization of a conventional kinesin motor expressed exclusively in neurons." in: Neuron, Vol. 12, Issue 5, pp. 1059-72, 1994 (PubMed).