TNFRSF25 抗体 (Tumor Necrosis Factor Receptor Superfamily, Member 25) (Extracellular Domain)

Details for Product anti-TNFRSF25 Antibody No. ABIN1002203
抗原
  • APO-3
  • DDR3
  • DR3
  • LARD
  • TNFRSF12
  • TR3
  • TRAMP
  • WSL-1
  • WSL-LR
  • Tnfrsf12
  • Wsl
  • TNFRSF25
  • TNF receptor superfamily member 25
  • tumor necrosis factor receptor superfamily, member 25
  • TNFRSF25
  • Tnfrsf25
抗原表位
Extracellular Domain
15
13
12
11
10
9
9
9
7
6
4
4
2
2
2
2
1
1
1
1
适用
人, 小鼠
175
55
33
3
2
2
2
2
1
1
宿主

154
28
克隆类型
多克隆
标记
This TNFRSF25 antibody is un-conjugated
9
6
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
应用范围
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
122
57
26
22
20
13
7
5
4
2
2
2
2
1
选项
免疫原 Rabbit polyclol DR3 antibody was raised against a peptide corresponding to amino acids in extracellular domain (ED) of human DR3 precusor.
Blocking Peptide Blocking peptide for this product available: ABIN1003922
亚型 IgG
纯化方法 Antibody is purified via DEAE-column chromatography.
Plasmids, Primers & others Plasmids, Primers & others TNFRSF25 products on genomics-online (e.g. as negative or positive controls)
抗原
别名 Death Receptor 3 (TNFRSF25 Antibody 摘要)
背景 Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kappaB activation.
途径 Apoptosis
应用备注 DR3 antibody can be used for detection of DR3 expression by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user.) Jurkat total cell lysate can be used as positive control and a 59 kDa band should be detected. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far. DR3 antibody is human and mouse reactive.
限制 仅限研究用
状态 Liquid
缓冲液 Antibody is supplied in PBS containing 0.02% sodium azide.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
储存条件 4 °C
有效期 12 months
有引用在: Marsters, Sheridan, Donahue, Pitti, Gray, Goddard, Bauer, Ashkenazi: "Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B." in: Current biology : CB, Vol. 6, Issue 12, pp. 1669-76, 1997 (PubMed).

Bodmer, Burns, Schneider, Hofmann, Steiner, Thome, Bornand, Hahne, Schröter, Becker, Wilson, French, Browning, MacDonald, Tschopp: "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)." in: Immunity, Vol. 6, Issue 1, pp. 79-88, 1997 (PubMed).

背景 Chinnaiyan, ORourke, Yu, Lyons, Garg, Duan, Xing, Gentz, Ni, Dixit: "Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95." in: Science (New York, N.Y.), Vol. 274, Issue 5289, pp. 990-2, 1996 (PubMed).

Kitson, Raven, Jiang, Goeddel, Giles, Pun, Grinham, Brown, Farrow: "A death-domain-containing receptor that mediates apoptosis." in: Nature, Vol. 384, Issue 6607, pp. 372-5, 1996 (PubMed).

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