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抗Human PFKFB3 抗体:
抗Mouse (Murine) PFKFB3 抗体:
抗Rat (Rattus) PFKFB3 抗体:
Human Polyclonal PFKFB3 Primary Antibody for IHC (p), WB - ABIN392768
Telang, Yalcin, Clem, Bucala, Lane, Eaton, Chesney: Ras transformation requires metabolic control by 6-phosphofructo-2-kinase. in Oncogene 2006
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Human Monoclonal PFKFB3 Primary Antibody for IP, ELISA - ABIN518808
Bao, Mukai, Hishiki, Kubo, Ohmura, Sugiura, Matsuura, Nagahata, Hayakawa, Yamamoto, Fukuda, Saya, Suematsu, Minamishima: Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo. in Molecular cancer research : MCR 2013
Show all 3 Pubmed References
Human Polyclonal PFKFB3 Primary Antibody for IP, WB - ABIN948248
Mendoza, Pocceschi, Kong, Leeper, Caro, Limesand, Burd: Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH. in Translational oncology 2012
Human Polyclonal PFKFB3 Primary Antibody for WB - ABIN518807
Yamamoto, Takano, Ishiwata, Ohmura, Nagahata, Matsuura, Kamata, Sakamoto, Nakanishi, Kubo, Hishiki, Suematsu: Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. in Nature communications 2014
Human Polyclonal PFKFB3 Primary Antibody for EIA, ICC - ABIN2728748
Reid, Lowman, Pan, Tran, Warmoes, Ishak Gabra, Yang, Locasale, Kong: IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. in Genes & development 2016
Human Polyclonal PFKFB3 Primary Antibody for IF (p), IHC (p) - ABIN744728
Fu, Shi, Westaway, Jhamandas: Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity. in The Journal of biological chemistry 2015
Study showed that endothelial cells (ECs)relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation.
Study provides evidence that PFKFB3 overexpression occupied a dominant position in sorafenib resistance of hepatocellular carcinoma cells.
This work has uncovered a novel function of the enzymes PFKFB3 and PFKFB4 (显示 PFKFB4 抗体) in ovarian cancer cells during mitotic arrest
PFK-2 seems to be a strategic element that links NADPH oxidase (显示 NOX1 抗体) activation and glycolysis modulation, and, as such, is proposed as a potential therapeutic target in inflammatory diseases.
Data suggest that hepatic glucokinase (显示 GCK 抗体) activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP (显示 GCKR 抗体)) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2/FBP2 (显示 KHSRP 抗体)); changes in glucokinase (显示 GCK 抗体) expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]
PFKFB3 was a novel downstream substrate of mTOR (显示 FRAP1 抗体) signaling pathway as PFKFB3 level was augmented after knocking down TSC2 (显示 TSC2 抗体) in THP1 (显示 GLI2 抗体) and OCI-AML3 (显示 RUNX2 抗体) acute myeloid leukemia (显示 BCL11A 抗体) cells.
Taken together, our study identifies PFKFB3 as a key TGFbeta1 (显示 TGFB1 抗体) effector protein that mediates TGFbeta1 (显示 TGFB1 抗体)'s effect on Snail (显示 SNAI1 抗体) expression, invasion, and glycolysis.
we investigate the crosstalk between PFKFB3 and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator (显示 C12orf5 抗体)), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR (显示 C12orf5 抗体) induction in HeLa cells in response to PFKFB3 knockdown
Knockdown of PFKFB3 by siRNAs significantly inhibited the proliferation and migration abilities of gastric cancer cells. Our data suggest that PFKFB3 might be a potential biomarker for gastric cancer and anti-neoplastic targeting gene.
The targeting of MCT1 (显示 CMA1 抗体) and PFKFB3 regulated cell proliferation.
the novel role of PFKFB3 in induction of paclitaxel resistance by raising lactate production and activating TLR4 (显示 TLR4 抗体) signaling, was characterized.
The PFKFB3-driven glycolysis selectively promotes the extrinsic antiviral capacity of macrophages, via metabolically supporting the engulfment and removal of virus-infected cells.
Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells.
overexpression of PFKFB3 in HEK293 cells potentiated insulin (显示 INS 抗体)-dependent phosphorylation of Akt (显示 AKT1 抗体) and Akt (显示 AKT1 抗体) substrates
Data show that inhibition of AMP (显示 TMPRSS5 抗体)-Activated kinase (AMPK (显示 PRKAA1 抗体)) or 6-phosphofructo-2-kinase-fructose-2,6-biphosphatase 3 (PFKFB3) results in enhanced cell death in mitosis.
Shear stress-mediated repression of endothelial cell metabolism via KLF2 (显示 KLF2 抗体) and PFKFB3 controls endothelial cell phenotype.
PFKFB3 is a promising target for the reduction of endothelial glycolysis and its related pathological angiogenesis
PFKFB3/iPFK2 responds to re-feeding, which in turn stimulates hypothalamic glycolysis and decreases hypothalamic AMPK (显示 PRKAA1 抗体) phosphorylation and alters neuropeptide expression in a pattern that is associated with suppression of food intake.
High-fat diet feeding stimulates intestine 6-phosphofructo-2-kinase expression and induces intestine inflammatory response.
a unique role for PFKFB3/iPFK2 in adipocytes with regard to diet-induced inflammatory responses in both adipose and liver tissues.
Synthesis and degradation of fructose 2,6-bisphosphate (By similarity).
, fructose-2,6-biphosphatase 3
, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
, 6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme
, 6PF-2-K/Fru-2,6-P2ase 3
, PFK/FBPase 3
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-like
, 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase
, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase
, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme
, fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase
, inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
, renal carcinoma antigen NY-REN-56
, inducible 6-phosphofructo-2-kinase
, 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme
, 6-P2ase liver isozyme
, 6PF-2-K/Fru-2,6-P2ase liver isozyme