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HMGCR 抗体

(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
HMGCR 抗体  (AA 629-888) HMGCR 抗体  (AA 629-888) HMGCR 抗体 (AA 629-888) (ABIN3022294)

HMGCR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

HMGCR 抗体  (AA 638-887) HMGCR 抗体  (AA 638-887) HMGCR 抗体 (AA 638-887) (ABIN7435559)

HMGCR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

HMGCR 抗体  (pSer872) HMGCR 抗体  (pSer872) HMGCR 抗体 (pSer872) (ABIN753283)

HMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

HMGCR 抗体 by Grade

Find HMGCR 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

HMGCR 抗体 by 适用

Find HMGCR 抗体 for a variety of species such as anti-Human HMGCR, anti-Rat HMGCR, anti-Mouse HMGCR. The species listed below are among those available. Click on a link to go to the corresponding products.

HMGCR 抗体 by 应用范围

Find HMGCR 抗体 validated for a specific application such as WB, FACS, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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HMGCR 抗体 by 抗原表位

Find HMGCR 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

HMGCR 抗体 by 克隆形成能力

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HMGCR 抗体 by 克隆

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HMGCR 抗体 by 标记

Find HMGCR 抗体 with a specific conjugate such as FITC, Biotin, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular HMGCR 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (2)
  • (9)
Cat. No. ABIN3022294
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7435559
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro)
Validations
  • (2)
  • (3)
Cat. No. ABIN753283
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7142292
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (3)
Cat. No. ABIN7259428
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6262303
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro)
Validations
  • (4)
  • (1)
Cat. No. ABIN709196
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC
Validations
  • (2)
Cat. No. ABIN7259042
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN5650001
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN5650000
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, FACS
Validations
  • (2)
Cat. No. ABIN570699
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IP
Validations
  • (1)
Cat. No. ABIN947978
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN7265326
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF, IC
Validations
  • (2)
Cat. No. ABIN7305994
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN753285
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our HMGCR 抗体

Hayashi, Nakazato, Morito, Sagi, Fujita, Anzai, Chida: "Fluvastatin is effective against thymic carcinoma." in: Life sciences, Vol. 240, pp. 117110, (2020) (PubMed).

Cheng, Zhu, Han, Zhang, Cui, Shen, Zhang, Yan, Prochownik, Li: "MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice." in: Cell death & disease, Vol. 8, Issue 7, pp. e2916, (2018) (PubMed).

Zanoni, Aiello, Arnoldi, Lammi: "Hempseed Peptides Exert Hypocholesterolemic Effects with a Statin-Like Mechanism." in: Journal of agricultural and food chemistry, Vol. 65, Issue 40, pp. 8829-8838, (2017) (PubMed).

Li, Xia, Xiong, Wang, Yan: "Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5635-5640, (2017) (PubMed).

Scharinger, Messner, Türkcan, Schuster, Vuorinen, Pitterl, Heinz, Arnhard, Laufer, Grimm, Stuppner, Oberacher, Eller, Ritsch, Bernhard: "Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice." in: Journal of molecular and cellular cardiology, Vol. 99, pp. 35-46, (2016) (PubMed).

Lee, Cho, Lee, Lee, Kim, Lee: "Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)." in: BMC complementary and alternative medicine, Vol. 16, pp. 51, (2016) (PubMed).

Yu, Zeng, Lei, Xiao, Li, Yuan, Lin: "Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 36, Issue 5, pp. 683-690, (2016) (PubMed).

Kou, Han, Wang, Huang, He, Han, Zhou, Ye, Li: "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." in: Life sciences, Vol. 151, pp. 50-60, (2016) (PubMed).

Gustbée, Tryggvadottir, Markkula, Simonsson, Nodin, Jirström, Rose, Ingvar, Borgquist, Jernström: "Tumor-specific expression of HMG-CoA reductase in a population-based cohort of breast cancer patients." in: BMC clinical pathology, Vol. 15, pp. 8, (2015) (PubMed).

Wu, He, Wang, Xue, Ning, Zou, Ye, Li, Wang, Pang: "The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 21, Issue 11, pp. 1373-81, (2014) (PubMed).

Aliases for HMGCR 抗体

3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) 抗体
3-hydroxy-3-methylglutaryl-CoA reductase L homeolog (hmgcr.L) 抗体
3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) 抗体
3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) 抗体
HMG Coenzyme A reductase (Hmgcr) 抗体
3-hydroxy-3-methylglutaryl-CoA reductase b (hmgcrb) 抗体
3H3M 抗体
BcDNA:LD15354 抗体
bro1 抗体
bs32f05.y1 抗体
CG10367 抗体
Clb 抗体
clb 抗体
Dmel\\CG10367 抗体
DmHMG-CoAr 抗体
Hmg 抗体
hmg-coa-r 抗体
HMG-CoAR 抗体
HmG-CoAR 抗体
hmgc 抗体
HMGCoAR 抗体
HMGCoAr 抗体
HMGCoARr 抗体
HMGCR 抗体
hmgcr 抗体
hmgcr2 抗体
HMGCR_Dm 抗体
HMGR 抗体
hmgrc 抗体
im:6912716 抗体
l(3)01152 抗体
l(3)04684 抗体
LDLCQ3 抗体
Red 抗体
zgc:110746 抗体
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