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抗Human EEF2 抗体:
抗Mouse (Murine) EEF2 抗体:
抗Rat (Rattus) EEF2 抗体:
Human Monoclonal EEF2 Primary Antibody for ICC, IHC - ABIN969090
Maggi, Kuchenruether, Dadey, Schwope, Grisendi, Townsend, Pandolfi, Weber: Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. in Molecular and cellular biology 2008
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Human Monoclonal EEF2 Primary Antibody for IF, ELISA - ABIN966028
Rose, Bisiani, Vistisen, Kiens, Richter: Skeletal muscle eEF2 and 4EBP1 phosphorylation during endurance exercise is dependent on intensity and muscle fiber type. in American journal of physiology. Regulatory, integrative and comparative physiology 2009
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the direct interaction of AKT2 (显示 AKT2 抗体) and EF2 was found to be dynamically regulated in embryonic rat cardiomyocytes
These results suggest that binding of eEF2 to the ribosome alters its conformation, resulting in a weakened affinity of eIF5A (显示 EIF5 抗体) and impairment of this interplay compromises cell growth due to translation elongation defects.
nuclear localization of active eEF-2 depends upon its interaction with p53 (显示 TP53 抗体), as cells lacking p53 (显示 TP53 抗体) contain less active eEF-2 in the nuclear compartment
High serum eukaryotic elongation factor 2 level is associated with non-small cell lung cancer.
Results indicated that the eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth.
The expression levels of three putative HA-regulated proteins (TALDO, ANXA1 (显示 ANXA1 抗体) and EF2) in control, H2O2-, HA- and HA/H2O2-treated OA chondrocytes were verified by Western blotting and the results indeed support the notion that HA acts in anti-oxidation
Data indicate that the accumulation of the cleaved C-terminal small fragment of eukaryotic elongation factor 2 (eEF2) in the nucleus, and C-terminal Src kinase (Csk (显示 CSK 抗体)) could enhance the proteolytic cleavage of eEF2.
Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
A single amino acid substitution in eukaryotic elongation factor 2 co-segregates with the disease phenotype of spinocerebellar ataxia 26.
EEF2 phosphorylation by cyclin A (显示 CCNA2 抗体)-cyclin-dependent kinase 2 (CDK2 (显示 CDK2 抗体)) on a novel site, serine 595 (S595), directly regulates T56 phosphorylation by eEF2K (显示 EEF2K 抗体).
Myostatin (显示 MSTN 抗体) inhibits eEF2K (显示 EEF2K 抗体)-eEF2 by regulating AMPK (显示 PRKAA1 抗体) to suppress protein synthesis.
IL-6 (显示 IL6 抗体) induces the activation of the Stat3 (显示 STAT3 抗体) signaling and promotes the downmodulation of the p90RSK (显示 RPS6KA1 抗体)/eEF2 and mTOR (显示 FRAP1 抗体)/p70S6K (显示 RPS6KB1 抗体) axes, while it does not affect the activation of AKT (显示 AKT1 抗体).
AMPKalpha2 (显示 PRKAA2 抗体) controls cardiac p70S6K (显示 RPS6KB1 抗体) under normoxia and regulates eEF-2 but not the mTOR (显示 FRAP1 抗体)-p70S6K (显示 RPS6KB1 抗体) pathway during ischemia.
The MKK3 (显示 MAP2K3 抗体)/6-p38gamma (显示 MAPK12 抗体)/delta pathway mediated an inhibitory phosphorylation of eukaryotic elongation factor 2 (eEF2) kinase, which in turn promoted eEF2 activation (dephosphorylation) and subsequent TNF-alpha (显示 TNF 抗体) elongation.
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development
induced by basic fibroblast growth factor (显示 FGF2 抗体) via mitogen-activated protein kinase (显示 MAPK1 抗体)
eEF-2 is activated by both lithium and GSK-3 (显示 GSK3b 抗体), whereas, lithium treatment and inhibition of GSK-3 (显示 GSK3b 抗体) have opposing effects on eEF-2.
eEF-2 phosphorylation has a role in protein synthesis for memory consolidation
A mouse that was mutant for the gene, Dph4 (显示 DNAJC24 抗体), was identified.
Eukaryotic elongation factor-2 (eEF2) may be a limiting factor in milk protein (显示 CSN2 抗体) synthesis (Review)
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.
eukaryotic translation elongation factor 2
, elongation factor 2-like
, elongation factor 2
, polypeptidyl-tRNA translocase
, elongation factor-2