Use your antibodies-online credentials, if available.
抗Human TMEM173 抗体:
抗Mouse (Murine) TMEM173 抗体:
抗Rat (Rattus) TMEM173 抗体:
Human Polyclonal TMEM173 Primary Antibody for ICC, IF - ABIN4356573
Furr, Chauhan, Moerdyk-Schauwecker, Marriott: A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells. in Journal of neuroinflammation 2011
Show all 12 Pubmed References
Human Polyclonal TMEM173 Primary Antibody for ICC, IF - ABIN4356571
Heiber, Barber: Evaluation of innate immune signaling pathways in transformed cells. in Methods in molecular biology (Clifton, N.J.) 2011
Show all 5 Pubmed References
Human Polyclonal TMEM173 Primary Antibody for WB - ABIN2783202
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004
Show all 4 Pubmed References
Human Monoclonal TMEM173 Primary Antibody for CyTOF, FACS - ABIN4899624
Schoggins, MacDuff, Imanaka, Gainey, Shrestha, Eitson, Mar, Richardson, Ratushny, Litvak, Dabelic, Manicassamy, Aitchison, Aderem, Elliott, García-Sastre, Racaniello, Snijder, Yokoyama, Diamond et al.: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. ... in Nature 2014
Show all 2 Pubmed References
Human T-lymphotropic virus 1 Tax (显示 CNTN2 抗体) protein impairs K63-linked ubiquitination of STING and disrupted the interactions between STING and TBK1 (显示 TBK1 抗体) to evade host innate immunity.
STING activated an antiviral/type I interferon (显示 IFNA 抗体) response with live but not killed S. aureus.
study identifies the AIM2 (显示 AIM2 抗体) inflammasome and cGAS/IFI16 (显示 IFI16 抗体)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
NEMO (显示 IKBKG 抗体) was critically involved in the cGAS-STING pathway.
Studied association of genetic variants of the MAVS, MITA and MFN2 genes with leprosy in Han Chinese from Southwest China; found no association between the variants and susceptibility to leprosy.
both IL-6 (显示 IL6 抗体) and RIG-I (显示 DDX58 抗体) are downstream molecules of STING along the DNA sensor pathway.
We discuss three newly described monogenic autoinflammatory diseases [deficiency of adenosine deaminase 2 (显示 CECR1 抗体) (DADA2), a subtype of macrophage activation syndrome (MAS (显示 MAS1 抗体)), and stimulator of interferon (显示 IFNA 抗体) genes (STING)-associated vasculopathy with onset in infancy (SAVI)], discuss the possibilities of somatic mosaicism and digenic inheritance, and give an update on new concepts in pathways involved in familial Mediterranean fever (显示 MEFV 抗体)
Structural analysis indicates that the 3 disease-associated mutations at positions 206, 281, and 284 of the STING protein define a novel cluster of amino acids with functional importance in the regulation of type I interferon (显示 IFNA 抗体) signaling
a critical role of p38 (显示 CRK 抗体)-mediated USP21 (显示 USP21 抗体) phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (显示 CRK 抗体)-USP21 (显示 USP21 抗体) axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
We conclude that the R71H-G230A-R293Q (HAQ) of TMEM173 is a null TMEM173 allele.
provide genetic evidence that cell-autonomous control of lentivirus infection in myeloid cells by SAMHD1 (显示 SAMHD1 抗体) limits virus-induced production of interferons and the induction of co-stimulatory markers
Data show that stimulator of interferon (显示 IFNA 抗体) genes (STING)-associated vasculopathy with onset in infancy (SAVI)-associated STING N153S mutation triggers IRF3 (显示 IRF3 抗体)-independent immune cell dysregulation and lung disease in mice.
These results highlight the crucial role of MFN1 (显示 MFN1 抗体) in maintaining the competency of the STING pathway.
to contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin (显示 BST2 抗体), a viral restriction factor
found that CCCP impairs the interaction between STING and TBK1 (显示 TBK1 抗体) and concomitantly triggers mitochondria fission.
Yersinia YopJ negatively regulates IRF3 (显示 IRF3 抗体)-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.
demonstrate that in colon tumor model, therapeutic anti-CD47 (显示 CD47 抗体) preferentially relies on STING-mediated DNA sensing in dendritic cells
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
transmembrane protein 173
, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
, endoplasmic reticulum IFN stimulator
, endoplasmic reticulum interferon stimulator
, mediator of IRF3 activation
, mitochondrial mediator of IRF3 activation
, stimulator of interferon genes protein
, Stimulator of interferon genes protein
, mitochondrial transmembrane protein 173