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This gene encodes a secreted peptide that displays antimicrobial activity against Gram-positive bacteria.
a model of CagA-directed REG3gamma expression in gastric epithelial cells via activation of the IL-11/gp130/STAT3 pathway
REG III was identified and expressed predominantly in pancreas and testis, but not in small intestine
PAP IB represents a good example of duplication and divergence, probably with the acquisition of new functions, thus participating in the evolution of the protein repertoire.
Reg3g acts as an immunosuppressive promoter by activating the JAK2/STAT3 signaling pathway in dendritic cells and triggering the generation of an immunosuppressive tumor microenvironment.
the secretion of regenerating islet-derived IIIgamma (RegIIIgamma) is responsible for the protective effect of Adipose-derived stem cells.
The study shows that cardiac stress activates Reg3gamma expression and p38 MAPK is an upstream regulator of Reg3gamma gene expression in heart. Altogether the data suggest Reg3gamma is associated with cardiac inflammatory signaling.
regenerating islet-derived gene gamma promotes beta cell regeneration and preserves beta cells from autoimmunity damage by increasing regulatory T cell differentiation and inducing tolerated dendritic cells.
Recombinant IFN-I or IFN-I expression induced by RIG-I promoted growth of intestinal organoids in vitro and production of the antimicrobial peptide regenerating islet-derived protein 3 gamma (RegIIIgamma).
Intestinal deficiency in REG3B or REG3G increases numbers of mucosa-associated bacteria and enhances bacterial translocation to the mesenteric lymph nodes and liver.
Administration of vancomycin downregulates RegIIIgamma and IL-17 expression in skin wounds.
REG3gamma-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum.
antibacterial function for lung epithelium through Stat3-mediated induction of Reg3gamma.
Expression of Reg3 proteins and Ang4 by goblet cells point to an important role for goblet cells in innate defense.
Reg-IIIgamma expression is mainly observed in epithelial cells of the airways and intestine, but not in the nervous system; expression levels show a gradually increasing pattern along with development.
Letter: aggregation status of PAP1 and PAP2 could change their role in regulating the inflammation in acute pancreatitis.
findings show that RegIIIgamma is essential for maintaining a ~50-micrometer zone that physically separates the microbiota from the small intestinal epithelial surface
Expression of Reg proteins in embryonic stem cells is modulated by Wnt/beta catenin signaling.
findings show that RegIIIgamma and its human counterpart, HIP/PAP, are directly antimicrobial proteins that bind their bacterial targets via interactions with peptidoglycan carbohydrate
antibacterial activities of mouse RegIIIgamma and its human ortholog, HIP/PAP, are tightly controlled by an inhibitory N-terminal prosegment that is removed by trypsin in vivo.
This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antibacterial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms.
, pancreatitis-associated protein 1B
, pancreatitis-associated protein IB
, reg III-gamma
, regenerating gene III
, regenerating islet-derived protein 3-gamma
, regenerating islet-derived protein III-gamma
, RegIII (gamma)
, generating islet-derived, mouse homolog 3 gamma
, pancreatitis-associated protein 3
, regenerating islet-derived protein 3 gamma
, regenerating islet-derived family member 3
, pancreatic thread protein
, regenerating islet-derived 3 alpha