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This gene encodes a secreted peptide that displays antimicrobial (显示 REG3A 蛋白)activity against Gram-positive bacteria.
a model of CagA (显示 S100A8 蛋白)-directed REG3gamma expression in gastric epithelial cells via activation of the IL-11 (显示 IL11 蛋白)/gp130 (显示 IL6ST 蛋白)/STAT3 (显示 STAT3 蛋白) pathway
REG III (显示 REG3A 蛋白) was identified and expressed predominantly in pancreas and testis, but not in small intestine
PAP IB represents a good example of duplication and divergence, probably with the acquisition of new functions, thus participating in the evolution of the protein repertoire.
Reg3g acts as an immunosuppressive promoter by activating the JAK2 (显示 JAK2 蛋白)/STAT3 (显示 STAT3 蛋白) signaling pathway in dendritic cells and triggering the generation of an immunosuppressive tumor microenvironment.
The study shows that cardiac stress activates Reg3gamma expression and p38 MAPK (显示 MAPK14 蛋白) is an upstream regulator of Reg3gamma gene expression in heart. Altogether the data suggest Reg3gamma is associated with cardiac inflammatory signaling.
Recombinant IFN-I or IFN-I expression induced by RIG-I (显示 DDX58 蛋白) promoted growth of intestinal organoids in vitro and production of the antimicrobial peptide (显示 CAMP 蛋白) regenerating islet-derived protein 3 gamma (RegIIIgamma).
Intestinal deficiency in REG3B or REG3G increases numbers of mucosa-associated bacteria and enhances bacterial translocation to the mesenteric lymph nodes and liver.
Administration of vancomycin downregulates RegIIIgamma and IL-17 (显示 IL17A 蛋白) expression in skin wounds.
antibacterial function for lung epithelium through Stat3 (显示 STAT3 蛋白)-mediated induction of Reg3gamma.
Expression of Reg3 (显示 REG3A 蛋白) proteins and Ang4 (显示 ANGPT4 蛋白) by goblet cells point to an important role for goblet cells in innate defense.
Reg (显示 KCNH2 蛋白)-IIIgamma expression is mainly observed in epithelial cells of the airways and intestine, but not in the nervous system; expression levels show a gradually increasing pattern along with development.
Letter: aggregation status of PAP1 and PAP2 (显示 MYBBP1A 蛋白) could change their role in regulating the inflammation in acute pancreatitis.
Expression of Reg (显示 KCNH2 蛋白) proteins in embryonic stem cells is modulated by Wnt (显示 WNT2 蛋白)/beta catenin (显示 CTNNB1 蛋白) signaling.
This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antibacterial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms.
, pancreatitis-associated protein 1B
, pancreatitis-associated protein IB
, reg III-gamma
, regenerating gene III
, regenerating islet-derived protein 3-gamma
, regenerating islet-derived protein III-gamma
, RegIII (gamma)
, generating islet-derived, mouse homolog 3 gamma
, pancreatitis-associated protein 3
, regenerating islet-derived protein 3 gamma
, regenerating islet-derived family member 3
, pancreatic thread protein
, regenerating islet-derived 3 alpha