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alpha-synuclein p.A53V homozygous mutation leads to a distinct phenotype of progressive parkinsonism and cognitive decline, commonly observed in patients with SNCA missense mutation or multiplications
Excessive iron and alpha-synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress.
RAP55/LSM14 binds directly the tubulin (显示 TUBB 蛋白) and that is implicated in the process of the mitotic spindle stabilization
RAP55 is important for the assembly of cytoplasmic mRNP granules and that PRMT1 (显示 PRMT1 蛋白) is required for RAP55A to localize to P-bodies.
The NS1 (显示 PTPN11 蛋白) protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection.
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
this protein family has evolved a common and fundamental role in the control of mRNA translation. Human RAP55A is an autoantigen detected in the serum of patients with primary biliary cirrhosis (PBC (显示 DLAT 蛋白)).
results suggest that LSm14A plays an important role in antiviral innate and adaptive immune responses by modulating MITA (显示 TMEM173 蛋白) level in a cell type-specific manner
The Scd6/Lsm14 protein xRAPB has properties different from RAP55 in selecting mRNA for early translation or intracellular distribution in Xenopus oocytes.
results suggest that xRAP55 is involved in translational repression of mRNA as a component of storage mRNPs [RNA-associated protein 55; RAP55]
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2\; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
LSM14 homolog A
, RNA-associated protein 55
, RNA-associated protein 55A
, family with sequence similarity 61, member A
, protein LSM14 homolog A
, protein SCD6 homolog
, putative alpha-synuclein-binding protein
, alpha synuclein binding protein
, RNA-associated protein 55A-A
, protein LSM14 homolog A-A
, LSM14A, SCD6 homolog A (S. cerevisiae)
, LSM14 protein homolog A
, LSM14A, SCD6 homolog A
, LSM14 homolog Ab
, LSM14A, SCD6 homolog Ab