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Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck-dependent activation of PKCdelta (显示 PKCd 蛋白), which stimulates PKCgamma (显示 PRKCG 蛋白), resulting in translocation of phosphorylated p47(phox).
HCK represents a novel target for therapeutic development in MYD88 (显示 MYD88 蛋白)-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88 (显示 MYD88 蛋白).
High HCK levels correlate with reduced survival of colorectal cancer patients and is associated with activated macrophages gene signature.
three-dimensional (3D) QSAR pharmacophore models were generated for Hck based on experimentally known inhibitors. A best pharmacophore model, Hypo1, was developed with high correlation coefficient (0.975), Low RMS deviation (0.60) and large cost difference (49.31), containing three ring aromatic and one hydrophobic aliphatic feature
we provide evidence for involvement of HCK and FGR (显示 FGR 蛋白) in FCRL4 (显示 FCRL4 蛋白)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (显示 FCRL4 蛋白) molecule.
Interaction with the Src (显示 SRC 蛋白) homology (SH3-SH2) region of the Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.
Interaction between Nef and Hck is important for Nef-dependent modulation of viral infectivity.
Data indicate that combined treatment using SFK (LYN (显示 LYN 蛋白), HCK, or FGR (显示 FGR 蛋白)) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (显示 TP53 蛋白) activity and enhancing targeting of acute myeloid leukemia (显示 BCL11A 蛋白) (AML (显示 RUNX1 蛋白)) stem cells.
The SRC (显示 SRC 蛋白) family tyrosine kinase (显示 TXK 蛋白) HCK and the ETS (显示 ETS1 蛋白) family transcription factors SPIB (显示 SPIB 蛋白) and EHF (显示 EHF 蛋白) regulate transcytosis across a human follicle-associated epithelium model.
This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase.
the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.
Hematopoietic Hck promotes tumorigenesis.
Data suggest that Hck is a key mediator of renal fibrosis
Data indicate that Src (显示 SRC 蛋白)-Family Kinases Hck and Fgr (显示 FGR 蛋白) regulate cytokine secretion by macrophages.
Hck is not only progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.
The Src (显示 SRC 蛋白) family kinases Hck, Fgr (显示 FGR 蛋白), and Lyn (显示 LYN 蛋白) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
tyrosine phosphorylation of WASP by Hck is required for proper macrophage functions
Hck is one of the very few effectors of preosteoclast recruitment described to date and thereby plays a critical role in bone remodeling.
Despite possessing enhanced killing, alveolar macrophage Hck/Fgr (显示 FGR 蛋白)/Lyn (显示 LYN 蛋白)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.
Taken together, PKR (显示 EIF2AK2 蛋白) and Hck were critical for DON-induced ribosomal recruitment of p38 (显示 CRK 蛋白), its subsequent phosphorylation, and, ultimately, p38 (显示 CRK 蛋白)-driven proinflammatory cytokine expression.
A truncated, mRNA-encoded src-related tyrosine kinase (显示 FRK 蛋白) HCK could function as an adaptor protein or as a competitive inhibitor in spermiogenesis or mature sperm functions.
the presence of mRNAs encoding for hck and hck-tr in testicular germ cells; hck-tr being translated during spermatogenesis and expressed on mature ejaculated bull spermatozoa.
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.
hemopoietic cell kinase
, non-receptor protein tyrosine kinase laloo
, tyrosine-protein kinase HCK-like
, hematopoietic cell kinase
, tyrosine-protein kinase HCK
, B cell/myeloid kinase
, B-cell/myeloid kinase
, hemopoietic cell tyrosine kinase