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Studies indicate that salivary scavenger and agglutinin (SALSA) binds to many microbes and endogenous complement components.
The data suggest that DMBT1 inhibition of twitching motility contributes to the mechanisms by which mucosal fluids protect against P. aeruginosa infection.
this study shows that SAG inhibits the Interaction of DC-SIGN (显示 CD209 蛋白) and Langerin (显示 CD207 蛋白) with oral microorganisms
These results support the hypothesis that genetic variation in DMBT1 may influence microbial defense.
DMBT1 DNA copy number variation does not affect susceptibility to Crohn's disease in Northern Europeans.
this study shows that salivary agglutinin modulates the lectin pathway of the complement system
DMBT1 can potentially serve as a biomarker for early Acute respiratory distress syndrome diagnosis and disease severity assessment.
The copy number variation at DMBT1 does not affect risk of developing age-related macular degeneration and can therefore be ruled out from future studies investigating the association of structural variation at 10q26 with age-related macular degeneration.
The basal and meconium-induced NO production in lung epithelial cells is positively regulated by DMBT1.
SALSA, together with fibronectin (显示 FN1 蛋白) and C1q, may be involved in the containment of injured placental structures into fibrinoids.
a novel role for interleukin-27 (IL-27 (显示 IL27 蛋白)) as mediator of intestinal epithelial barrier protection mediated via DMBT1 and IDO1 (显示 IDO1 蛋白)
DMBT1 functions as an important endothelium-derived ECM (显示 MMRN1 蛋白) protein that is able to bind angiogenic factors and promote adhesion, migration, proliferation, and angiogenesis as well as vascular repair.
Data show that deletion of hensin from intercalated cells results in the absence of typical alpha-intercalated cells and the consequent development of complete distal renal tubular acidosis (dRTA).
Carboxyl-terminal Asp (显示 C3 蛋白)(D) -3, Thr (显示 TRH 蛋白)(T) -2, Lys (显示 LYZ 蛋白)(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 (显示 SLC9A3R1 蛋白) and PDZK1/CAP70 (显示 PDZK1 蛋白).
binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D (显示 SFTPD 蛋白)
Muclin is a Golgi cargo receptor that binds to regulated secretory proteins under the mildly acidic pH conditions that exist in the trans-Golgi network
Mouse embryonic stem cells seeded on hensin formed hemispheric epithelial structures whose outermost layer terminally differentiated to an epithelium that resembled the visceral endoderm.
The results identify a novel mammary tumor susceptibility locus in mice and support a role for DMBT1 in suppression of mammary tumors in both mice and women.
Dmbt1(-/-) mice display enhanced susceptibility to dextran sulfate sodium-induced colitis and elevated Tnf, Il6, and Nod2 expression levels during inflammation.
Muclin deficiency impairs trafficking of regulated proteins to a stimulus-releasable pool in the exocrine pancreas
Demonstrate that galectin-3 (显示 LGALS3 蛋白) plays a critical role in hensin ECM (显示 MMRN1 蛋白) assembly by oligomerizing secreted monomeric hensin.
Data suggest that DMBT1 is secreted by oviduct epithelium and plays role in sperm-ovum interactions during in vitro fertilization.
Involvement of AKAP4 (显示 AKAP4 蛋白) in the formation of the fibrous sheath on boar precursor sperm cells and the phosphorylation of pro-AKAP4 (显示 AKAP4 蛋白) as an early step in the signal transduction pathway gated by DMBT1 that leads to sperm selection through acrosome alteration.
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.
, deleted in malignant brain tumors 1 protein
, glycoprotein 340
, salivary agglutinin
, surfactant pulmonary-associated D-binding protein
, deleted in malignant brain tumors 1 pseudogene
, glycoprotein 300
, mucin-like glycoprotein
, deleted in malignant brain tumors 1
, hypothetical protein