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Results show negative regulation of HDAC1 (显示 HDAC1 蛋白) by a Cul3 (显示 CUL3 蛋白)-REN (显示 REN1 蛋白) E3 ubiquitin ligase (显示 MUL1 蛋白) complex.
REN (显示 REN1 蛋白) is upregulated by neurogenic signals (retinoic acid, EGF (显示 EGF 蛋白), and NGF (显示 NGFB 蛋白)) in embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation.
REN (显示 REN1 蛋白) protein enhances caspase-3 (显示 CASP3 蛋白) activation and antagonizes the Shh (显示 SHH 蛋白) pathway suggesting that this gene may represent a restraint of Shh (显示 SHH 蛋白) signaling.
The current study provides evidence for a possible association of renin gene polymorphisms with essential hypertension in a Han population of northern China.
Plasma renin activity is associated with cardiovascular mortality or heart failure readmissions.
In patients with established atherosclerotic disease undergoing carotid endarterectomy, plasma renin and aldosterone concentrations were not associated with atherosclerotic plaque characteristics. Plasma renin concentration was positively associated with the occurrence of major secondary vascular events.
These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development
The genotypes of REN, AT1R (显示 AGTR1 蛋白) and AT2R (显示 AGTR2 蛋白) were not associated with the development of preeclampsia in South African Black women.
Urinary angiotensinogen (显示 AGT 蛋白) and renin excretion are elevated in CKD patients. Both parameters are negatively associated with eGFR (显示 EGFR 蛋白) and these associations are independent of urinary albumin (显示 ALB 蛋白) excretion
Autosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen (显示 AGT 蛋白) and renin excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease.
Prospective study of consecutive cardiac disease patients referred for cardiac catheterization has revealed distinct cardiac disease condition-associated differences in the frequencies of elevations in plasma renin, plasma aldosterone concentration, and the aldosterone-renin ratio
Renin-angiotensin system transgenic mouse model suggests that renal injury in preeclampsia may be mediated through local VEGF (显示 VEGFA 蛋白).
Data suggest mild primary aldosteronism (PA), where plasma renin activity is not as suppressed, is susceptible to dietary sodium influences on renin and ARR (显示 SAG 蛋白) (aldosterone to renin ratio). Optimal screening for PA should occur under conditions of high dietary sodium intake (rather than condition of low dietary sodium intake as frequently prescribed for patients with hypertension, which may be a symptom of PA).
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
, BTB/POZ domain-containing protein KCTD11
, retinoic acid, EGF, and NGF upregulated
, renin 1 structural
, angiotensin-forming enzyme
, renin precursor, renal