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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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10 | ABIN1859566 | ICC IHC WB | Rabbit | IgG | AA 22-379 | Log in to see | Polyclonal | 0 | ||
1 | ABIN1862825 | ICC IHC (fro) IHC (p) ELISA WB | Rabbit | IgG | Log in to see | Polyclonal | 0 |
General |
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抗原 | Kininogen 1 (KNG1) 抗体 |
适用 | 人, 小鼠, 大鼠 其他选择 |
宿主 | 兔 其他选择 |
克隆类型 | |
标记 | 非结合性 其他选择 |
应用范围 |
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
其他选择
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Supplier | Log in to see |
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特异性 | KNG1 Antibody detects endogenous levels of total KNG1 |
交叉反应 | 人, 小鼠, 大鼠 |
纯化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific). |
免疫原 | A synthesized peptide derived from human KNG1 |
亚型 | IgG |
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抗原 | |
别名 | KNG1 (KNG1 Antibody 摘要) |
背景 |
Description: 1 Kininogens are inhibitors of thiol proteases, (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes, (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action), (5) LMW-kininogen inhibits the aggregation of thrombocytes, (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. Gene: KNG1 |
分子量 | 72kDa |
基因ID | 3827 |
UniProt | P01042 |
途径 | ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process |
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应用备注 | WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500 |
限制 | 仅限研究用 |
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状态 | Liquid |
浓度 | 1 mg/mL |
缓冲液 | Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol. |
储存液 | Sodium azide |
注意事项 | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
储存条件 | -20 °C |
储存方法 | Store at -20 °C.Stable for 12 months from date of receipt |
有效期 | 12 months |
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