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Human Cathepsin G Protein expressed in Human - ABIN3119673
Towstyka, Shiromizu, Keitelman, Sabbione, Salamone, Geffner, Trevani, Jancic: Modulation of γδ T-cell activation by neutrophil elastase. in Immunology 2017
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CTSG was increased in peripheral blood mononuclear cells and muscle tissues of dermatomyositis (DM) patients, and CTSG activity was higher in the serum of DM patients
CatG can be used as a novel marker to distinguish different NK cell subsets and MARS116 is applicable to determine cell surface CatG activity by flow cytometry.
Results provide evidence that cathepsin G (GC) activates IGF-1R (显示 IGF1R 蛋白) by stimulating IGF-1 (显示 IGF1 蛋白) release from MCF-7 cells, and that IGF-1R (显示 IGF1R 蛋白) activation is required for CG-induced cell aggregation.
Cleavage of the alarmins by Human mast cell chymase (显示 CMA1 蛋白) and human neutrophil cathepsin G suggests a function in regulating excessive inflammation.
Data show that lactoferrin (LF (显示 LTF 蛋白)) increases the catalytic activity of cathepsin G (CatG) at physiological concentration.
CatG is an essential protease for regulating MHC I molecules
Patients with certain polymorphisms in the CTSG gene had lower risk for chronic postsurgical pain compared with wild-types.
These in vivo data provide, for the first time, compelling evidence of the collateral involvement of cathepsin G, NE, and proteinase 3 (显示 PRTN3 蛋白) in cigarette smoke-induced tissue damage and emphysema
expression levels of ELANE (显示 ELANE 蛋白) and CTSG were determined by quantitative real-time PCR
Elastase and cathepsin G are elevated in the plasma of HD patients, originating from primed PMNLs. In these patients, chronic elevation of these enzymes contributes to cleavage of VE-cadherin (显示 CDH5 蛋白) and possible disruption of endothelial integrity.
these findings present evidence of an arterial-specific recruitment pattern centered on CatG-instructed adhesion strengthening. The inhibition of this process could provide a novel strategy for treatment of arterial inflammation with limited side effects.
Cathepsin G activity may impair efferocytosis, which could lead to an accumulation of lesion-associated apoptotic cells and the accelerated progression of early atherosclerotic lesions to more complex lesions in Apoe (显示 APOE 蛋白)(-/-) mice.
SerpinB1 (显示 SERPINB1 蛋白) is critical for maintaining polymorphonuclear neutrophils survival by antagonizing intracellular cathepsin G activity.
Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.
NADPH oxidase (显示 NOX1 蛋白) in antimicrobial host defense against A. fumigatus and B. cepacia, whereas the proteases neutrophil elastase (显示 ELANE 蛋白), cathepsin G, and lysosomal cysteine protease cathepsin C/ dipeptidyl peptidase I (显示 CTSC 蛋白) are dispensable
Cathepsin G and neutrophil elastase (显示 ELANE 蛋白) contribute to lung-protective immunity against mycobacterial infections in mice.
Inhibition of TGF-beta (显示 TGFB1 蛋白) significantly reduces microvessel density in mammary tumor-induced bone lesions, mediated by decreased expression of both vascular endothelial growth factor (VEGF (显示 VEGF 蛋白)) and monocyte chemotactic protein (MCP)-1 (显示 CPT1B 蛋白).
neutrophil elastase (显示 ELANE 蛋白) and cathepsin G are inhibited by PAI-1 (显示 SERPINE1 蛋白) mutants
cathepsin G activity at the tumor-bone interface plays an important role in mammary tumor-induced osteolysis through RANKL (显示 TNFSF11 蛋白)
both Cat-G and PAR(4 (显示 F2RL3 蛋白)) play key roles in generating and/or amplifying relapses in ulcerative colitis
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
, vimentin-specific protease