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Elevated plasma ACE2 is significantly associated with more advanced LA structural remodeling in atrial fibrillation.
Overexpression of ACE2 in monocytes led to reduced endothelial adhesion, transmigration and downregulation of adhesion-related molecules and results in atherosclerosis.
These results indicated that aberrant methylation of the ACE2 promoter may be associated with EH risk. In addition, sex may significantly influence ACE2 methylation.
ACE2 rs2106809 is an important predictive factor of the response to antihypertensive treatment with ACE (显示 ACE 蛋白) inhibitors in Chinese female hypertensive patients.
In islets from db/db (显示 LEPR 蛋白) mice, ACE2 over-expression increased intracellular calcium influx and restored impaired mitochondrial oxidation, potentially causing an increase in GSIS. These results shed light on the potential roles of ACE2 in mitochondrial metabolism, moreover, may improve our understanding of diabetes.
ACE2 may have a role in silent atherosclerosis in patients with chronic kidney disease; it counterbalances the vasoconstrictor adverse effects of angiotensin II by its conversion
This study reveals an elevated serum concentration of ACE2 and independent associations between serum ACE2 and echocardiographic parameters in hypertensive patients.
The findings of this study indicate that ACE-2 activity is reduced in AD and is an important regulator of the central classical ACE-1 (显示 ACE 蛋白)/Ang II (显示 AGT 蛋白)/AT1R (显示 AGTR1 蛋白) axis of renin (显示 REN 蛋白)-angiotensin system, and also that dysregulation of this pathway likely plays a significant role in the pathogenesis of Alzheimer's disease.
Overexpression of ACE2 ameliorates Abeta (显示 APP 蛋白)-induced inflammatory response by activating the ACE2/Ang-(1 (显示 ANGPT1 蛋白)-7)/Mas (显示 MAS1 蛋白) axis in human RPE (显示 RPE 蛋白) cells.
Although further studies are required to determine how clusterin (显示 CLU 蛋白) suppresses non-specific cellular uptake in phagocytes, our data suggest that clusterin (显示 CLU 蛋白) plays a key role in the stealth effect of not only pegylated nanoparticles but also non-pegylated nanoparticles.
Exogenous ACE2 alters angiotensin peptide metabolism in the kidneys of Col4a3 (显示 COL4a3 蛋白) knockout mice and attenuates the progression of Alport syndrome nephropathy.
Profound augmentation of ACE2 confined to the circulation failed to ameliorate the glomerular lesions and hyperfiltration characteristic of early diabetic nephropathy.
Nrf2-mediated stimulation of intrarenal Renin-Angiotensin syste, (CAE2 and MasR) gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes.
Ultra-high doses did not influence the ACE2/AT2R (显示 AGTR2 蛋白)/Mas (显示 MAS1 蛋白) axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin (显示 FN1 蛋白) expression in db/db (显示 LEPR 蛋白) mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage.
Altogether, our study demonstrates that HFD feeding increases RAS activity and mediates glycemic dysregulation likely through loss of ACE2 present outside the islets but independently of changes in islet ACE2.
Results suggest that angiotensin converting enzyme 2 may reduce anxiety-like behavior by activating central Mas (显示 MAS1 蛋白) receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala.
These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.
ACE2 overexpression significantly reduced the myocardial infarction-induced increase in apoptosis, macrophage infiltration, and HMGB1 (显示 HMGB1 蛋白) and proinflammatory cytokine expression.
ACE2 regulates vascular function by modulating nitric oxide release.
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
sporadic non-synonymous substitutions reduced the level of rh-ACE2 protein expression and did not support severe acute respiratory syndrome coronavirus entry effectively
In a pig model of acute pulmonary embolism leading to cardiac arrest, captopril infusion was associated with less mean right ventricular pressure overload after resuscitation, compared with saline infusion. The reduction in systemic and pulmonary vascular resistance associated with captopril may be by inhibiting the ACE (显示 ACE 蛋白)-Ang II (显示 AGT 蛋白)-AT1R (显示 AGTR1 蛋白) axis and activating the ACE2/Ang-(1 (显示 ANGPT1 蛋白)-7)/Mas (显示 MAS1 蛋白) axis.
This study produced the full-length porcine ACE2 cDNA sequence and found polyunsaturated fatty acids could downregulate the expression of ACE2.
activation of the central rennin (显示 CYM 蛋白)-angiotensin system in animals with chronic heart failure involves an imbalance of ACE (显示 ACE 蛋白) and ACE2 in regions of the brain that regulate autonomic function.
Overexpression of ACE2 inhibited atherosclerotic plaque inflammation response in hypercholesterolemic rabbits.
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
, angiotensin-converting enzyme 2
, angiotensin-converting enzyme homolog
, metalloprotease MPROT15
, peptidyl-dipeptidase A
, angiotensin I converting enzyme 2
, anigotensin-converting enzyme-related carboxypeptidase
, renal angiotensin-converting enzyme 2