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The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. 再加上，我们可以发ATRX 抗体 (127) 和 ATRX 蛋白 (4)和数多这个蛋白质的别的产品。
Structural and biochemical characterization of DAXX (显示 DAXX ELISA试剂盒)-ATRX interaction.
Structural basis for DAXX (显示 DAXX ELISA试剂盒) interaction with ATRX.
Review of research progress of TERT (显示 TERT ELISA试剂盒)-mediated and ATRX-mediated telomere maintenance and neuroblastoma (显示 ARHGEF16 ELISA试剂盒), especially high-risk tumors
This study demonstrated the ATRX loss in glioneuronal tumors with neuropil-like islands.
6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1 (显示 IDH1 ELISA试剂盒)/IDH2 (显示 IDH2 ELISA试剂盒), ATRX, and 1p/19q results.
The chromatin remodeling enzyme ATRX is a regulator of therapy induced senescence and drives cells into this state via multiple mechanisms.
The present study explored the structural consequences influenced by two observed mutations V194I and C220R on ADD domain of ATRX protein by applying all atom molecular dynamics (MD) simulation.
Study demonstrate that the retention of ATRX expression in all oligodendroglial tumor nuclei strongly supports the diagnosis of oligodendroglioma. Conversely, its loss in tumor astrocytic nuclei favors the diagnosis of astrocytoma.
Given the high frequency of ATRX and DAXX (显示 DAXX ELISA试剂盒) mutations in cancer, these chromatin regulators likely play a key role in pathogenesis [review]
Data suggest that identification of IDH1 (显示 IDH1 ELISA试剂盒)-R132H and ATRX loss status in the primary-recurrent gliomas may aid in treatment strategy selection, therapeutic trial design, and clinical prognosis evaluation.
mosaic loss of ATRX expression in the central nervous system leads to endocrine defects and decreased body size and has a negative impact on learning and memory.
The results suggest that ATRX is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 (显示 PARP1 ELISA试剂盒) activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.
Our study highlights the importance of the cooperation between Rad54 (显示 RAD54L ELISA试剂盒) and Mus81 (显示 MUS81 ELISA试剂盒) for mediating DNA DSB repair and restraining chromosome missegregation.
The long noncoding RNA, TERRA (显示 DMRT2 ELISA试剂盒) can bind both in cis (显示 CISH ELISA试剂盒) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (显示 DMRT2 ELISA试剂盒) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (显示 DMRT2 ELISA试剂盒) activates, ATRX represses gene expression.
The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.
ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.
Daxx (显示 DAXX ELISA试剂盒) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (显示 HELLS ELISA试剂盒) levels are low.
A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.
We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.
ATRX promotes the incorporation of histone H3.3 (显示 H3F3A ELISA试剂盒) at particular transcribed genes and facilitates transcriptional elongation through G-rich sequences.
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
ATP-dependent helicase ATRX
, DNA dependent ATPase and helicase
, X-linked helicase II
, X-linked nuclear protein
, Zinc finger helicase
, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
, helicase 2, X-linked
, transcriptional regulator ATRX
, alpha thalassemia/mental retardation syndrome X-linked homolog
, helicase II
, HP1 alpha-interacting protein
, alpha thalassemia/mental retardation syndrome (X-linked)
, heterochromatin protein 2
, DNA repair and recombination protein RAD54-like
, RAD54 homolog