helicase 2, X-linked (ATRX) ELISA试剂盒

The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. 再加上,我们可以发ATRX 抗体 (126)ATRX 蛋白 (4)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
 ATRX ATRX 546 P46100
大鼠 ATRX ATRX 246284  
小鼠 ATRX ATRX 22589 Q61687
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适于 ATRX 相互作用对的更多 ELISA 试剂盒

Human helicase 2, X-linked (ATRX) interaction partners

  1. Both primary Alternative lengthening of telomeres(ALT) -positive and ATRX/DAXX (显示 DAXX ELISA试剂盒)-negative PanNETs are independently associated with aggressive clinicopathologic behavior and displayed reduced recurrence-free survival. In contrast, ALT activation and loss of ATRX/DAXX (显示 DAXX ELISA试剂盒) are both associated with better overall survival in patients with metastases

  2. Whole-exome sequencing has identified recurrent mutations in the genes DAXX (显示 DAXX ELISA试剂盒) and ATRX, which correlate with loss of protein expression and alternative lengthening of telomeres (ALT).ALT and DAXX (显示 DAXX ELISA试剂盒)/ATRX loss in PanNETs was associated with shorter disease-free survival (DFS (显示 FST ELISA试剂盒)) and disease-specific survival (DSS (显示 NR0B1 ELISA试剂盒)) and likely plays a significant role in driving metastatic disease

  3. The results of this study support an important role for ATRX loss and acquisition of ALT in the biology of NF1 (显示 NF1 ELISA试剂盒)-associated gliomas, particularly diffuse and high-grade tumors developing in adults.

  4. We propose that mutations in alpha thalassemia-mental retardation syndrome X-linked (ATRX)/death-domain associated protein (DAXX (显示 DAXX ELISA试剂盒)) prime alternative lengthening of telomeres activation by disrupting telomeric heterochromatin.

  5. Structural and biochemical characterization of DAXX (显示 DAXX ELISA试剂盒)-ATRX interaction.

  6. Structural basis for DAXX (显示 DAXX ELISA试剂盒) interaction with ATRX.

  7. Review of research progress of TERT (显示 TERT ELISA试剂盒)-mediated and ATRX-mediated telomere maintenance and neuroblastoma (显示 ARHGEF16 ELISA试剂盒), especially high-risk tumors

  8. This study demonstrated the ATRX loss in glioneuronal tumors with neuropil-like islands.

  9. 6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1 (显示 IDH1 ELISA试剂盒)/IDH2 (显示 IDH2 ELISA试剂盒), ATRX, and 1p/19q results.

  10. The chromatin remodeling enzyme ATRX is a regulator of therapy induced senescence and drives cells into this state via multiple mechanisms.

Mouse (Murine) helicase 2, X-linked (ATRX) interaction partners

  1. Gene expression changes in the Atrx-null retina indicate defective synaptic structure and neuronal circuitry, suggest excitotoxic mechanisms of neurodegeneration, and demonstrate that common targets of ATRX in the forebrain and retina may contribute to similar neuropathological processes underlying cognitive impairment and visual dysfunction in ATR-X syndrome.

  2. mosaic loss of ATRX expression in the central nervous system leads to endocrine defects and decreased body size and has a negative impact on learning and memory.

  3. The results suggest that ATRX is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 (显示 PARP1 ELISA试剂盒) activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.

  4. Our study highlights the importance of the cooperation between Rad54 (显示 RAD54L ELISA试剂盒) and Mus81 (显示 MUS81 ELISA试剂盒) for mediating DNA DSB repair and restraining chromosome missegregation.

  5. The long noncoding RNA, TERRA (显示 DMRT2 ELISA试剂盒) can bind both in cis (显示 CISH ELISA试剂盒) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (显示 DMRT2 ELISA试剂盒) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (显示 DMRT2 ELISA试剂盒) activates, ATRX represses gene expression.

  6. The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.

  7. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  8. Daxx (显示 DAXX ELISA试剂盒) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (显示 HELLS ELISA试剂盒) levels are low.

  9. A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.

  10. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

ATRX 抗原简介

Antigen Summary

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with ATRX

  • ATRX, chromatin remodeler (ATRX) 抗体
  • ATRX, chromatin remodeler (Atrx) 抗体
  • RAD54 like (S. cerevisiae) (Rad54l) 抗体
  • 4833408C14Rik 抗体
  • AI447451 抗体
  • ATR2 抗体
  • DXHXS6677E 抗体
  • HP1-BP38 抗体
  • Hp1bp2 抗体
  • Hp1bp38 抗体
  • JMS 抗体
  • MRXHF1 抗体
  • MRXS3 抗体
  • Rad54 抗体
  • RAD54L 抗体
  • SFM1 抗体
  • SHS 抗体
  • XH2 抗体
  • Xnp 抗体
  • ZNF-HX 抗体

Protein level used designations for ATRX

ATP-dependent helicase ATRX , DNA dependent ATPase and helicase , X-linked helicase II , X-linked nuclear protein , Zinc finger helicase , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) , helicase 2, X-linked , transcriptional regulator ATRX , alpha thalassemia/mental retardation syndrome X-linked homolog , helicase II , pABP-2 , XNP , HP1 alpha-interacting protein , alpha thalassemia/mental retardation syndrome (X-linked) , heterochromatin protein 2 , DNA repair and recombination protein RAD54-like , RAD54 homolog , mHR54 , mRAD54

GENE ID SPECIES
100455265 Pongo abelii
546 Homo sapiens
246284 Rattus norvegicus
449625 Pan troglodytes
22589 Mus musculus
19366 Mus musculus
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