ATRX 抗体
(helicase 2, X-linked (ATRX))
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
recommended
ATRX 适用: 人, 小鼠 WB, IF, IHC (p), ICC, IP 宿主: 兔 Polyclonal unconjugated
recommended
recommended
ATRX 抗体 by Grade
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ATRX 抗体 by 适用
Find ATRX 抗体 for a variety of species such as anti-Human ATRX, anti-Mouse ATRX, anti-Rabbit ATRX. The species listed below are among those available. Click on a link to go to the corresponding products.
ATRX 抗体 by 抗体来源
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ATRX 抗体 by 克隆形成能力
Find available monoclonal or polyclonal ATRX 抗体. Click on a link to go to the corresponding products.
ATRX 抗体 by 克隆
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Latest Publications for our ATRX 抗体
: "Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood." in: Journal of neuro-oncology, Vol. 142, Issue 3, pp. 435-444, (2019) (PubMed).: "A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer." in: Oncology letters, Vol. 16, Issue 5, pp. 6652-6662, (2018) (PubMed).
: "Dysregulation of select ATP-dependent chromatin remodeling factors in high trait anxiety." in: Behavioural brain research, Vol. 311, pp. 141-6, (2016) (PubMed).
: "Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas." in: Nature communications, Vol. 6, pp. 6140, (2015) (PubMed).
: "Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort." in: Oncotarget, Vol. 6, Issue 18, pp. 15871-81, (2015) (PubMed).
: "ATRX represses alternative lengthening of telomeres." in: Oncotarget, Vol. 6, Issue 18, pp. 16543-58, (2015) (PubMed).
: "TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast." in: British journal of cancer, Vol. 113, Issue 8, pp. 1244-8, (2015) (PubMed).
: "Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors." in: Frontiers in behavioral neuroscience, Vol. 9, pp. 313, (2015) (PubMed).
: "Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 32, Issue 8, pp. 783-90, (2014) (PubMed).
: "Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas." in: Clinical neuropathology, Vol. 33, Issue 2, pp. 108-11, (2014) (PubMed).
Aliases for ATRX 抗体
ATRX, chromatin remodeler (ATRX) 抗体ATRX, chromatin remodeler (Atrx) 抗体
alpha thalassemia/mental retardation syndrome X-linked L homeolog (atrx.L) 抗体
alpha thalassemia/mental retardation syndrome X-linked homolog (human) (atrx) 抗体
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