gamma-Glutamylcyclotransferase 蛋白 (GGCT)

The protein encoded by GGCT catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. 再加上,我们可以发gamma-Glutamylcyclotransferase 抗体 (67)gamma-Glutamylcyclotransferase 试剂盒 (7)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
GGCT 110175 Q9D7X8
大鼠 GGCT GGCT 362368  
GGCT 79017 O75223
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Showing 9 out of 13 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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大肠杆菌(E. Coli) His tag   50 μg Log in to see 4 Days
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大肠杆菌(E. Coli) His tag Validation with Western Blot 10 μg Log in to see 8至11个工作日
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大肠杆菌(E. Coli) His-SUMO Tag 100 μg Log in to see 11 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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酵母菌 Cow His tag   1 mg Log in to see 60至71个工作日
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大肠杆菌(E. Coli) His tag   10 μg Log in to see 15至16个工作日
$300.00
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非结合性   1 mg Log in to see 6 Days
$4,125.00
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GGCT 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human ,
, ,

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Human gamma-Glutamylcyclotransferase (GGCT) interaction partners

  1. GGCT is highly upregulated in HGSC tissues and associated with FIGO stage, lymph node metastasis and ascitic fluid volume. High expression of GGCT is associated with poor survival in HGSC patients.

  2. Taken together, the results indicate that PHB2 (显示 PHB2 蛋白) plays a central role in p21 (显示 CDKN1A 蛋白) upregulation following GGCT knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21 (显示 CDKN1A 蛋白).

  3. GGCT plays a critical role in glioma cell proliferation and may be a potential cancer therapeutic target.

  4. GGCT is promising as a diagnostic marker and a therapeutic target for various cancers. This review summarizes these interesting findings.

  5. G6PD (显示 G6PD 蛋白), GGCT, IDH1 (显示 IDH1 蛋白), isocitrate dehydrogenase 2 (显示 IDH2 蛋白) (NADP+,mitochondrial) (IDH2 (显示 IDH2 蛋白)) and glutathione S-transferase pi 1(GSTP1 (显示 GSTP1 蛋白)), five of the critical components of GSH pathway, contribute to chemoresistance.

  6. GGCT plays a critical role in lung cancer cell proliferation.

  7. Transcriptional silencing of the C7orf24 gene in the non-malignant cells is elicited through heterochromatin formation in its promoter region.

  8. increased expression of GGCT was a common event among invasive esophageal squamous cell carcinoma tissues regardless of the depth of invasion. Lymph node metastasis and tumor differentiation correlated with GGCT expression

  9. C7orf24 has been recognized as a potent marker for bladder and breast cancers. Studies on the role of gamma-glutamylcyclotransferace may aid in the control of malignant transformation of these cancers.

  10. GGCT may be a biomarker of tumors in a limited range of organs.

蛋白简介gamma-Glutamylcyclotransferase (GGCT)

蛋白简介

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with GGCT

  • gamma-glutamylcyclotransferase b (ggctb)
  • gamma-glutamylcyclotransferase (GGCT)
  • gamma-glutamylcyclotransferase (ggct)
  • gamma-glutamyl cyclotransferase (ggct)
  • gamma-glutamyl cyclotransferase (Ggct)
  • A030007L17Rik 蛋白
  • AA673177 蛋白
  • C7orf24 蛋白
  • CRF21 蛋白
  • fj35c05 蛋白
  • GCTG 蛋白
  • GGC 蛋白
  • ggct 蛋白
  • Ggctl1 蛋白
  • RGD1304876 蛋白
  • RGD1562590 蛋白
  • wu:fj35b07 蛋白
  • wu:fj35c05 蛋白
  • zgc:56140 蛋白

Protein level used designations for GGCT

gamma-glutamylcyclotransferase , gamma-glutamyl cyclotransferase , gamma-glutamyl cyclotransferase-like 1 , cytochrome c-releasing factor 21 , gamma -glutamyl cyclotransferase

GENE ID SPECIES
406278 Danio rerio
463327 Pan troglodytes
611603 Canis lupus familiaris
613056 Xenopus (Silurana) tropicalis
695547 Macaca mulatta
100528263 Ictalurus punctatus
110175 Mus musculus
362368 Rattus norvegicus
79017 Homo sapiens
533374 Bos taurus
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