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Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. 再加上，我们可以发和数多这个蛋白质的别的产品。
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Cow (Bovine) Monoclonal CLTC Primary Antibody for ICC, FACS - ABIN152766
Fernandez, McVicker, Tuma, Tuma: Ethanol selectively impairs clathrin-mediated internalization in polarized hepatic cells. in Biochemical pharmacology 2009
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Human Polyclonal CLTC Primary Antibody for IF (p) - ABIN891159
Kuhn, Vanhecke, Michen, Blank, Gehr, Petri-Fink, Rothen-Rutishauser: Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages. in Beilstein journal of nanotechnology 2014
Cow (Bovine) Monoclonal CLTC Primary Antibody for WB - ABIN265878
Grossman, Ebke, Beight, Jang, Crabb, Hagstrom: Protein partners of dynamin-1 in the retina. in Visual neuroscience 2013
The B-Raf (显示 SNRPE 抗体) inhibitor PLX4032 induces DR5 (显示 TNFRSF10B 抗体) upregulation exclusively in Ras-mutant cancer cells; this effect is dependent on Ras/c-Raf (显示 RAF1 抗体)/MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体) signaling activation.
RNA sequencing identified in both an AKAP9 (显示 AKAP9 抗体)-BRAF (显示 BRAF 抗体) gene fusion
a new somatic BRAF (显示 BRAF 抗体) splicing mutation, was identified.
RAS-ERK (显示 EPHB2 抗体) signaling in BRAF (显示 BRAF 抗体) mutant melanomas is critical for regulating active chromatin state and recruitment of RNA polymerase II (显示 0 抗体) at mutant TERT (显示 TERT 抗体) promoters. Our study provides evidence that the mutant TERT (显示 TERT 抗体) promoter is a key substrate downstream of the RAS-ERK (显示 EPHB2 抗体) pathway.
the presence of the BRAF (显示 BRAF 抗体) (V600E) mutation may be negatively correlated with partial aggressive clinicopathological features of pediatric papillary thyroid cancer (PTC (显示 F9 抗体)).
Vemurafenib, inhibiting BRAF (显示 BRAF 抗体) signaling, shifted the balance of activatory and inhibitory NK ligands on melanoma cells and displayed immunoregulatory effects on NK-cell functional activities
We have found a higher incidence of axLN metastases in BRAF (显示 BRAF 抗体) mutated NSCLC patients than described in non-BRAF (显示 BRAF 抗体) mutated NSCLC patients. Examination of the axilla should be a routine part of physical examination in this genetically distinct subgroup of lung cancer patients.
Braf (显示 BRAF 抗体) mutations served as biomarkers for response to anti-EGFR (显示 EGFR 抗体) monoclonal antibodies in colorectal cancer.[review]
BRAF mutation, rather than KRAS, was a significant prognostic factor in Korean colorectal cancer patients at both early and advanced stages.
The lack of KRAS, NRAS (显示 NRAS 抗体), BRAF (显示 BRAF 抗体), and PIK3CA (显示 PIK3CA 抗体) mutation in our study may suggest that a subset of eyelid sebaceous carcinomas is unlike that of eyelid sebaceous carcinomas of western countries.
The clathrin heavy chain CHC-1 negatively regulates pulling forces acting on centrosomes during interphase and on spindle poles during mitosis in one-cell C. elegans embryos.
Inactivating epn-1 (显示 EPN1 抗体) or chc-1 disrupts engulfment by impairing actin polymerization. CHC-1 is enriched on extending pseudopods together with EPN-1 (显示 EPN1 抗体), in an EPN-1 (显示 EPN1 抗体)-dependent manner.
These results indicate that a high level of CHC activity is required for receptor-mediated endocytosis in nonneuronal cells but is largely dispensable for maintenance of synaptic vesicle pools.
Loss of SNX-1 (显示 SNX1 抗体), RME-8, or the clathrin chaperone Hsc70 (显示 HSPA8 抗体)/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 (显示 RAE1 抗体) to the lysosome.
Taken together, these results demonstrate that Japanese encephalitis virus enters porcine kidney epithelial PK15 cells through cholesterol- and clathrin-mediated endocytosis.
Clathrin plays a crucial role in meiotic spindle function in maturing oocytes, possibly through spindle stabilization
three different clathrin-box motif peptides can each simultaneously bind not only to the previously characterized clathrin-box site but also to the W-box site and the beta-arrestin splice loop site on a single TD.
Structure of clathrin coat with bound Hsc70 (显示 HSPA8 抗体) and auxilin (显示 DNAJC6 抗体).
clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats
our results demonstrate that CKAP5 (显示 CKAP5 抗体) is important in oocyte maturation and early embryo development, and CKAP5 (显示 CKAP5 抗体) might work together with CLTC in mouse oocyte maturation
SP-A (显示 SFTPA1 抗体) transiently enhances the basal protein expression of CHC and alpha-adaptin (显示 AP2A2 抗体).
MiR (显示 MLXIP 抗体)-199a-5p suppresses tumorigenesis by targeting CLTC in hepatocellular carcinoma.
PTEN-like domains of GAK and auxilin are not essential for Hsc70-dependent chaperoning and uncoating of clathrin, but depending on the tissue, these domains appear to increase the efficiency of these co-chaperones.
The clathrin-mediated endocytic machinery combines with Dab2 (显示 DAB2 抗体) to facilitate the endocytosis of RGD-integrin-beta3 clusters.
Taken together, these results show that CLTC plays an important role in spindle assembly and chromosome congression through a microtubule correlation mechanism during mouse oocyte maturation.
Auditory inner hair cells use dynamin-dependent endocytosis via clathrin-mediated endocytosis.
Data indicate that dynamin (显示 DNM1 抗体), clathrin, adaptor protein complex-2 (AP2 (显示 TFAP2A 抗体)), and amphiphysin (显示 AMPH 抗体) contribute to the depolarization-evoked entry in endocytosis.
This study reveals a novel functional role of clathrin-coated structure in GMR (显示 CSF2RA 抗体) signaling and the oncogenesis of JAK2V617F.
The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis.
Data indicate that MTV1 (AT3G16270) and AGD5 (AT5G54310) Physically Interact with clathrin.
study presents a genetic characterization of the role of clathrin in endocytosis and auxin-mediated plant development; data demonstrate a fundamental role for clathrin function in cell polarity, growth, patterning, and organogenesis
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.
94 kDa B-raf protein
, B-Raf proto-oncogene serine/threonine-protein kinase (p94)
, murine sarcoma viral (v-raf) oncogene homolog B1
, proto-oncogene B-Raf
, serine/threonine-protein kinase B-raf
, v-raf murine sarcoma viral oncogene homolog B1
, clathrin heavy chain
, Clathrin Heavy Chain family member (chc-1)
, clathrin heavy chain 1
, clathrin heavy-chain
, clathrin, heavy polypeptide (Hc)
, clathrin heavy chain on chromosome 17
, clathrin, heavy polypeptide-like 2
, clathrin, heavy chain (Hc)
, clathrin, heavy chain (Hc) L homeolog