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Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. 再加上，我们可以发aHSP 抗体 (52) 和 aHSP 蛋白 (16)和数多这个蛋白质的别的产品。
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In the presence of free alpha subunits and H2O2, both HbA and HbE (显示 HBe1 ELISA试剂盒) showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit (显示 POLG ELISA试剂盒) and under the same oxidative conditions, these events are substantially increased for HbE (显示 HBe1 ELISA试剂盒) compared to HbA
Findings indicate that alpha-hemoglobin-stabilizing protein (AHSP) expression is a biomarker of hemoglobin (显示 HBB ELISA试剂盒) H (HbH (显示 HBA1 ELISA试剂盒)) disease severity and infer an important role of AHSP in modulating the pathophysiology of this disease.
AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.
AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.
In maturing RBC (显示 CACNA1C ELISA试剂盒) progenitors AHSP bind to free alpha-globin (显示 HBA1 ELISA试剂盒) chains to increase the HbA production. (Review)
analysis showed binding of STAT3 (显示 STAT3 ELISA试剂盒) to AHSP promoter and binding was significantly augmented with IL6 (显示 IL6 ELISA试剂盒) stimulation and upon alpha-globin (显示 HBA1 ELISA试剂盒) overexpression
The relationship between AHSP gene expression, disease severity, and the beta/alpha globin (显示 HBA1 ELISA试剂盒) mRNA ratio was studied among different homozygote beta-thalassemia patients.
alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy (显示 GCG ELISA试剂盒)-alpha-hemoglobin and weakens the iron-oxygen bond.
alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA with hydrogen peroxide.
AHSP acts as a molecular chaperone (显示 HSP90AA1 ELISA试剂盒) by rapidly binding and stabilizing met-alpha hemichrome folding intermediates
role of alpha-hemoglobin stabilizing protein in hemoglobin assembly
Endogenous AHSP is not limiting for alpha-globin (显示 HBA-A1 ELISA试剂盒) detoxification in beta-thalassemic mice.
activin A (显示 INHBA ELISA试剂盒) does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh (显示 SHH ELISA试剂盒)-dependent mechanism
Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.
These results support the hypothesis that EKLF (显示 KLF1 ELISA试剂盒) acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin (显示 HBB ELISA试剂盒) genes and indicate that EKLF (显示 KLF1 ELISA试剂盒) may play similar roles for other erythroid genes.
developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF (显示 KLF1 ELISA试剂盒) might be one of the steps necessary for the switch-on of the mammalian adult beta globin (显示 HBB ELISA试剂盒) gene transcription
AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly
The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein (显示 PRNP ELISA试剂盒) on the cell surface is reported.
Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).
alpha hemoglobin stabilizing protein
, erythroid associated factor
, alpha hemoglobin stabilising protein
, alpha-hemoglobin-stabilizing protein
, erythroid differentiation associated factor
, erythroid differentiation-related factor
, erythroid-associated factor