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XAF1 encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family.
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Human Polyclonal XAF1 Primary Antibody for IHC (p), IHC - ABIN252333
Kempkensteffen, Fritzsche, Johannsen, Weikert, Hinz, Dietel, Riener, Moch, Jung, Krause, Miller, Kristiansen: Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer. in BMC cancer 2009
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Human Polyclonal XAF1 Primary Antibody for IHC (p), WB - ABIN537343
Xia, Novak, Lewis, Duckett, Phillips: Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP. in Molecular and cellular biochemistry 2006
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Human Polyclonal XAF1 Primary Antibody for IHC, ELISA - ABIN1030804
Levin, Iannuzzi, Montgomery, Trudeau, Datta, Adrianto, Chitale, McKeigue, Rybicki: Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene. in PLoS ONE 2014
Human Polyclonal XAF1 Primary Antibody for WB - ABIN223375
Chen, Wang, Huang, Lin, Wu, Sun, Chang, Feng: Combination of DNA methylation inhibitor 5-azacytidine and arsenic trioxide has synergistic activity in myeloma. in European journal of haematology 2009
this study uncovers an important role for XAF1-MT2A (显示 MT2 抗体) antagonism as a linchpin to govern cell fate under various stressful conditions including heavy metal exposure.
XAF1 expression was markedly altered in non-small cell lung cancer tumor samples when compared to that found in normal lung tissues.
XAF1 expression was associated with VM in ovarian cancer, suggesting a potential role of XAF1 in the formation of VM in EOC.
XAF1 may be a candidate tumor suppressor in neuroblastoma (显示 ARHGEF16 抗体)
Dysfunction of XAF1 is frequent and is regulated through XAF1 promoter hypermethylation in gastric cancer. Circulating methylated XAF1 DNA was associated with tumor burden and malignant progression, which may be a valuable biomarker for diagnosis of gastric cancer, predicting patients' prognosis and monitoring tumor recurrence after surgery treatment.
XAF1 promoter hypomethylation is associated with high-grade gliomas.
human genome-wide gene expression profile assay was used to screen the targets of miR (显示 MLXIP 抗体)-3131. The overexpressed miR (显示 MLXIP 抗体)-3131 could lead to a significant decrease of DTHD1 and XAF1 mRNA level.
XAF1 acts as a feedback regulator of the TNF (显示 TNF 抗体) receptor signaling pathway to suppress NF-kappaB (显示 NFKB1 抗体) activation
Taken together, our results suggest that ROS (显示 ROS1 抗体) generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 and GADD45alpha (显示 GADD45A 抗体) expression by MAPK (显示 MAPK1 抗体) and functional p53 (显示 TP53 抗体).
Expression of XAF1 and TAp73 (显示 TP73 抗体) was also upregulated in casticin-treated T24 cells.
Interferon gamma (显示 IFNG 抗体) induces XAF1 and Noxa (显示 PMAIP1 抗体) expression and potentiates apoptosis by STAT3 (显示 STAT3 抗体) activation
XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1 (显示 TIE1 抗体), Ang-1 (显示 ANGPT1 抗体), Ang-2 (显示 ANGPT2 抗体) and c-Myc (显示 MYC 抗体) may be mechanistically responsible for the observed antiangiogenesis effect.
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene.
XIAP-associated factor 1
, BIRC4 binding protein
, BIRC4-binding protein
, F-box protein 39
, novel TRAF-type zinc finger protein