anti-WD Repeat and FYVE Domain Containing 3 (WDFY3) 抗体

WDFY3 encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. 再加上,我们可以发和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
WDFY3 23001 Q8IZQ1
WDFY3 72145 Q6VNB8
WDFY3 305164  
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antibodies-online.cn销售最多的anti-WDFY3 抗体

Showing 10 out of 95 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-WDFY3 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human brain Host:  Rabbit  Target Name:  WDFY3  Sample Tissue:  Human Fetal Liver  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2至3个工作日
$289.00
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Cow 非结合性 WB WB Suggested Anti-WDFY3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Human Muscle 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 EM, ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: WDFY3 Antibody [NBP1-03332] - FFPE section of human ovarian carcinoma. Immunohistochemistry-Paraffin: WDFY3 Antibody [NBP1-03332] - FFPE section of human glioblastoma dilution of 1:5,000 (0.2ug/ml). Detection: DAB 100 μL Log in to see 7至9个工作日
$556.31
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豚鼠 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
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小鼠 山羊 非结合性 ELISA, WB   100 μg Log in to see 6至7个工作日
$358.02
详细
非结合性 ELISA, WB 50 μg Log in to see 2至3个工作日
$446.88
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非结合性 IHC Immunohistochemistry-Paraffin: WDFY3 Antibody  - Saining of human gallbladder shows moderate cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10至13个工作日
$491.63
详细
HRP ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-WDFY3 Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm, Nucleus, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) WDFY3 Antibody. (D) Composite. Western blot analysis of Human HeLa and 293Trap cell lysates showing detection of 395.2 kDa WDFY3 protein using Rabbit Anti-WDFY3 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HeLa and 293Trap cell lysates. Load: 15 µg . Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 395.2 kDa. 100 μg Log in to see 2至3个工作日
$487.03
详细
FITC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-WDFY3 Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm, Nucleus, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) WDFY3 Antibody. (D) Composite. Western blot analysis of Human HeLa and 293Trap cell lysates showing detection of 395.2 kDa WDFY3 protein using Rabbit Anti-WDFY3 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HeLa and 293Trap cell lysates. Load: 15 µg . Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 395.2 kDa. 100 μg Log in to see 2至3个工作日
$492.09
详细
Alkaline Phosphatase (AP) ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-WDFY3 Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm, Nucleus, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) WDFY3 Antibody. (D) Composite. Western blot analysis of Human HeLa and 293Trap cell lysates showing detection of 395.2 kDa WDFY3 protein using Rabbit Anti-WDFY3 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HeLa and 293Trap cell lysates. Load: 15 µg . Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 395.2 kDa. 100 μg Log in to see 2至3个工作日
$494.62
详细

引用最多的anti-WDFY3 抗体

  1. Human Polyclonal WDFY3 Primary Antibody for EM, ICC - ABIN315857 : Sommi, Necchi, Vitali, Montagna, De Luigi, Salmona, Ricci, Solcia: PaCS is a novel cytoplasmic structure containing functional proteasome and inducible by cytokines/trophic factors. in PLoS ONE 2013 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal WDFY3 Primary Antibody for ELISA, WB - ABIN949075 : Orosco, Ross, Cates, Scott, Wu, Sohn, Pleasure, Pleasure, Adamopoulos, Zarbalis: Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. in Nature communications 2014 (PubMed)

  3. Cow (Bovine) Polyclonal WDFY3 Primary Antibody for WB - ABIN2784358 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)
    Show all 2 Pubmed References

更多抗WDFY3的相互作用对抗体

Human WD Repeat and FYVE Domain Containing 3 (WDFY3) interaction partners

  1. we demonstrate that normally ALFY attenuates the canonical Wnt (显示 WNT2 抗体) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 (显示 DVL3 抗体) and not of Dvl1 (显示 DVL1 抗体) or Dvl2 (显示 DVL2 抗体).

  2. ALFY binds selectively to LC3C (显示 MAP1LC3C 抗体) and the GABARAPs through a LC3 (显示 MAP1LC3A 抗体)-interacting region in its WD40 domain (显示 DCAF12L2 抗体).

  3. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others

  4. Data suggest that p62 (显示 GTF2H1 抗体) and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy.

  5. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.

  6. Alfy might target cytosolic protein aggregates for autophagic degradation.

Mouse (Murine) WD Repeat and FYVE Domain Containing 3 (WDFY3) interaction partners

  1. Data provide a novel association between WDFY3 and the RANKL (显示 TNFSF11 抗体)-induced osteoclastogenesis pathway via the modulation of TRAF6 (显示 TRAF6 抗体).

  2. Alfy translocalization likely is involved in the pathogenesis of amyotrophic lateral sclerosis.

  3. Wdfy3 is important in regulating neural progenitor divisions, neural migration, cerebral expansion and functional organization in the developing brain. Loss-of-function leads to pathological changes characteristic of autism spectrum disorders.

  4. gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 (显示 NPAT 抗体) and E16 (显示 SLC7A5 抗体) embryonic brain, but became diffuse after birth

WDFY3 抗原简介

蛋白简介

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.

Gene names and symbols associated with WDFY3

  • WDFY family member 4 (WDFY4) 抗体
  • WD repeat and FYVE domain containing 3 (WDFY3) 抗体
  • WD repeat and FYVE domain-containing protein 3 (MGYG_03998) 抗体
  • WD repeat and FYVE domain containing 3 (Wdfy3) 抗体
  • 2610509D04Rik 抗体
  • ALFY 抗体
  • AW319683 抗体
  • B930017C24 抗体
  • Bchs 抗体
  • BWF1 抗体
  • D5Ertd66e 抗体
  • Ggtb3 抗体
  • mKIAA0993 抗体
  • ZFYVE25 抗体

Protein level used designations for WDFY3

WD repeat and FYVE domain containing 3 , WD repeat and FYVE domain-containing protein 3 , autophagy-linked FYVE protein , beach domain, WD repeat and FYVE domain-containing protein 1 , galactosyltransferase 3 beta 1, 4

GENE ID SPECIES
100157904 Sus scrofa
461201 Pan troglodytes
10029110 Arthroderma gypseum CBS 118893
422613 Gallus gallus
23001 Homo sapiens
487841 Canis lupus familiaris
537096 Bos taurus
72145 Mus musculus
305164 Rattus norvegicus
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