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WDFY3 encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. 再加上，我们可以发和数多这个蛋白质的别的产品。
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Human Polyclonal WDFY3 Primary Antibody for EM, ICC - ABIN315857
Sommi, Necchi, Vitali, Montagna, De Luigi, Salmona, Ricci, Solcia: PaCS is a novel cytoplasmic structure containing functional proteasome and inducible by cytokines/trophic factors. in PLoS ONE 2013
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Human Monoclonal WDFY3 Primary Antibody for ELISA, WB - ABIN949075
Orosco, Ross, Cates, Scott, Wu, Sohn, Pleasure, Pleasure, Adamopoulos, Zarbalis: Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. in Nature communications 2014
Cow (Bovine) Polyclonal WDFY3 Primary Antibody for WB - ABIN2784358
Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005
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we demonstrate that normally ALFY attenuates the canonical Wnt (显示 WNT2 抗体) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 (显示 DVL3 抗体) and not of Dvl1 (显示 DVL1 抗体) or Dvl2 (显示 DVL2 抗体).
ALFY binds selectively to LC3C (显示 MAP1LC3C 抗体) and the GABARAPs through a LC3 (显示 MAP1LC3A 抗体)-interacting region in its WD40 domain (显示 DCAF12L2 抗体).
increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others
Data suggest that p62 (显示 GTF2H1 抗体) and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy.
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
Alfy might target cytosolic protein aggregates for autophagic degradation.
Data provide a novel association between WDFY3 and the RANKL (显示 TNFSF11 抗体)-induced osteoclastogenesis pathway via the modulation of TRAF6 (显示 TRAF6 抗体).
Alfy translocalization likely is involved in the pathogenesis of amyotrophic lateral sclerosis.
Wdfy3 is important in regulating neural progenitor divisions, neural migration, cerebral expansion and functional organization in the developing brain. Loss-of-function leads to pathological changes characteristic of autism spectrum disorders.
gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 (显示 NPAT 抗体) and E16 (显示 SLC7A5 抗体) embryonic brain, but became diffuse after birth
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.
WD repeat and FYVE domain containing 3
, WD repeat and FYVE domain-containing protein 3
, autophagy-linked FYVE protein
, beach domain, WD repeat and FYVE domain-containing protein 1
, galactosyltransferase 3 beta 1, 4