Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) ELISA试剂盒

PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. 再加上,我们可以发PTPN22 抗体 (82)PTPN22 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
小鼠 PTPN22 PTPN22 19260 P29352
PTPN22 26191 Q9Y2R2
大鼠 PTPN22 PTPN22 295338  
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3.9 pg/mL 15.6-1000 pg/mL   96 Tests 15至18个工作日
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Mouse (Murine) Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. these findings highlight PTPN22 as a novel regulator of dectin-1 signals, providing a link between genetically conferred perturbations of innate receptor signaling and the risk of autoimmune disease

  2. PTPN22 role in CD8-positive t cells activation.

  3. This finding shows that autophagy and NLRP3 inflammasome activation are connected, and that PTPN22 plays a key role in the regulation of those 2 pathways.

  4. Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13. The numbers and function of viral-specific CD4 T lymphocytes is greatly enhanced, whereas expression of the IFNbeta-induced IL-2 repressor, cAMP-responsive element modulator is reduced.

  5. we have discovered that inactivation of Ptpn22 or Mll3 greatly accelerated PI3K-driven mammary tumorigenesis

  6. Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement.

  7. PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation.

  8. PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 ligand intercellular adhesion molecule-1 (ICAM-1).

  9. in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.

  10. PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

  11. collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals

  12. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 phosphorylation, but reduced levels of mature IL-1beta.

  13. We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.

  14. this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis

  15. report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.

  16. our data suggest a critical role for GITR in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior

  17. Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity.

  18. lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3(+) Treg and Tr1 cells

  19. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes

  20. T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases.

Human Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. Our data showed that the PTPN22 R620W polymorphism is a risk factor for Takayasu's arteritis (TA) (CC vs. CT: OR 4.3, p = 0.002, and C vs. T: OR 4.1, p = 0.003); however, the PTPN22 R263Q and - 1123G/C polymorphisms are not associated with this autoimmune disease. In addition, the PTPN22 CGT haplotype, which carries the minor allele of the PTPN22 C1858T variant, was also associated with TA susceptibility.

  2. results showed that the PTPN22 +788 G>A polymorphism is not associated with RA susceptibility in western Mexican population, whereas the presence of G/A genotype is associated with increased PTPN22 mRNA expression in RA patients

  3. PTPN22 rs2476601 polymorphism frequency was higher in rheumatoid arthritis and undifferentiated arthritis vs the general population; however, this was significantly different only for rheumatoid arthritis vs control group.

  4. The findings of the current investigation suggested a significant association between the rs2476601 polymorphism of PTPN22 gene and Alopecia Areata. The C-allele and CC-genotype carriers at this locus have a lower risk of Alopecia Areata.

  5. In a genome-wide association study, we identified rs2476601 in PTPN22 as a non-HLA variant that associates with risk of liver injury caused by multiple drugs and validated our finding in a separate cohort.

  6. Studied association of protein tyrosine phosphatase non-receptor type 22 (PTPN22) single nucleotide polymorphisms (SNPs) with the increased activation and proliferation of T helper cells, specifically CD154 antigen expression and CD+ T cells, in subjects with rheumatoid arthritis.

  7. PTPN22 is down-regulated in patients with rheumatoid arthritis carrying the risk alleles of PTPN22 rs2488457 and rs2476601.

  8. The T allele is associated only in cases with Juvenile idiopathic arthritis (JIA) and it may be considered as risk allele for certain JIA subtypes in Egyptian patients.

  9. PTPN22 is implicated in signalling pathways involved in the autoimmune and autoinflammatory processes underlying rheumatoid arthritis; a nonsynonymous polymorphism of PTPN22 (R620W), located in the first proline-rich motif of LYP, was described as major susceptibility factor

  10. A rare variant of PTPN22 was linked to Hashimoto's thyroiditis in a Chinese pedigree.

  11. Lack of association between PTPN22 R620W variant and IBD susceptibility in Moroccan patients.

  12. RA samples with PTPN2:rs478582 and/or PTPN22:rs2476601 were more positive for MAP than samples without polymorphisms. Combined occurrence of PTPN2:rs478582 and PTPN22:rs2476601 in association with the presence of MAP has significantly increased T-cell response and elevated IFN-gamma expression in RA samples.

  13. The authors propose a novel mechanism of action of PTPN22 risk allele through the generation of cytotoxic CD4(+) T cells and identify EOMES(+) CD4(+) T cells as a relevant T-cell subset in RA pathogenesis.

  14. our data indicate a novel role for PTPN2 and PTPN22 in controlling intestinal microbiota composition and further elucidate the complex interplay between genetic risk factors, intestinal microbiota and disease course in IBD patients.

  15. Significant associations were found for SH2B3 T allele and PTPN22 A allele and autoimmune hepatitis

  16. A significant association was detected between the variant genotype of the PTPN22 gene (C1858T, rs2476601) and T1DM in Kuwaiti Arabs. HLA-DQ2 and DQ8 alleles showed a strong association with T1DM. Of T1DM patients having the variant TT-genotype of the PTPN22 gene, 93% had at least one DQ2 allele and 60% had either a DQ2 or a DQ8 allele. TT homozygotes had either DR3-DRB5 or DRB3-DRB4 genotypes.

  17. PTPN22 and CTLA-4 polymorphisms are associated with Autoimmune polyglandular syndromes and differentiate between polyglandular and monoglandular autoimmunity.

  18. gene expression levels of PTPN22 were higher in the alopecia areata patients in Iranian population; association between the PTPN22 genetic variation was not confirmed by this study

  19. The data presented here suggests that the T allele of PTPN-22 C1858T polymorphism might be a risk factor for T1D development in Saudi children.

  20. The variability in PTPN22 haplotypes suggests that the genetic signature of LADA is independent and should not be considered a hybrid form of T1DM and T2DM.

PTPN22 抗原简介

Antigen Summary

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PTPN22

  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) 抗体
  • protein tyrosine phosphatase, non-receptor type 22 (PTPN22) 抗体
  • protein tyrosine phosphatase, non-receptor type 22 (Ptpn22) 抗体
  • 70zpep 抗体
  • LYP 抗体
  • LYP1 抗体
  • LYP2 抗体
  • PEP 抗体
  • PTPN8 抗体

Protein level used designations for PTPN22

PEST domain-enriched tyrosine phosphatase , hematopoietic cell protein-tyrosine phosphatase 70Z-PEP , protein tyrosine phosphatase, non-receptor type 8 , tyrosine-protein phosphatase non-receptor type 22 , PEST-domain phosphatase , lymphoid phosphatase , lymphoid-specific protein tyrosine phosphatase

GENE ID SPECIES
19260 Mus musculus
26191 Homo sapiens
295338 Rattus norvegicus
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