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Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. 再加上，我们可以发Tumor Necrosis Factor Receptor Superfamily, Member 11b 抗体 (177) 和 Tumor Necrosis Factor Receptor Superfamily, Member 11b 试剂盒 (91)和数多这个蛋白质的别的产品。
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Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin (显示 CALCA 蛋白) and osteoprotegerin, whereas the osteocalcin (显示 BGLAP 蛋白) expression significantly increased during calcification.
Elevated serum ferritin (显示 FTL 蛋白) concentrations and bone remodeling marker, osteoprotegerin, are independent predictors of hip fracture in postmenopausal women hospitalized for fragility fracture.
Results showed that colorectal liver metastasis tissues exhibited significantly reduced expression of osteoprotegerin compared to primary colorectal carcinomas and normal colorectal mucosa. This reduced expression was significantly associated with the extent of colorectal liver metastasis, including multiplicity of metastatic tumors, involvement of the bilateral hepatic lobes, and higher histological grade.
Data indicate that the RANKL (显示 TNFSF11 蛋白)/RANK/OPG system is deregulated in post-menopausal women at high risk for breast cancer and in women with circulating tumor cells. Thus, serum levels of RANKL/OPG (显示 TNFSF11 蛋白) are potentially indicative of predisposition and progression of breast cancer in humans.
High OPG expression is associated with triple negative breast cancer.
show for the first time that OPG improves risk stratification for cardiovascular events in a non-dialysis chronic kidney disease population
OPG has a role in cancer progression, especially breast cancer [review]
OPG rs2073618 polymorphism could be a possible genetic marker for the prediction of increased risk for carotid plaque burden as a measure of advanced subclinical atherosclerosis in T2DM subjects.
The compound with greatest potential is E05657 with high activity and low effective concentration in the HTS (显示 APCDD1 蛋白) system. It increases the OPG/RANKL (显示 TNFSF11 蛋白) ratio and OPG secretion, decreases the NFATc1 (显示 NFATC1 蛋白) expression, and reduces osteoclastogenesis in vitro
OPG T950C polymorphism might be associated with an increased osteoporosis risk in the Chinese population
findings demonstrate that mTORC1 activation-stimulated RANKL (显示 TNFSF11 蛋白) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (显示 TNFSF11 蛋白) axis via negative regulation of beta-catenin (显示 CTNNB1 蛋白).
RANK/RANKL (显示 TNFSF11 蛋白) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.
endocortical resorption is driven by reduced OPG (显示 TNFSF11 蛋白) rather than elevated RANKL (显示 TNFSF11 蛋白) expression
Diabetes significantly increased OPG (显示 TNFSF11 蛋白) and the OPG (显示 TNFSF11 蛋白)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (显示 TNFSF11 蛋白) and reduced TRAIL expression, thus increasing cardiac OPG (显示 TNFSF11 蛋白)/TRAIL ratio.
These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (显示 TNFSF11 蛋白) interaction and osteoclastogenesis.
OPG (显示 TNFSF11 蛋白) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.
These data suggested that OPG (显示 TNFSF11 蛋白) played an important role in maintaining the homeostasis of articular cartilage of femoral head.
Data show that p38alpha (显示 MAPK14 蛋白) mitogen-activated protein kinase (显示 MAPK1 蛋白) (MAPK (显示 MAPK1 蛋白)) in paired related homeobox 1 (显示 PRRX1 蛋白) protein (Prx1 (显示 PRDX1 蛋白)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.
OPG (显示 TNFSF11 蛋白) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.
the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice
The OPG (显示 TNFSF11 蛋白) expression levels decreased while those of RANKL (显示 TNFSF11 蛋白) and RUNX2 (显示 RUNX2 蛋白) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.
Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (显示 TNFSF11 蛋白) mRNA expression.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
osteoclastogenesis inhibitory factor
, tumor necrosis factor receptor superfamily member 11B
, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
, tumor necrosis factor receptor superfamily, member 11b
, tumor necrosis factor receptor superfamily member 11B-like