anti-Transmembrane Channel-Like 8 (TMC8) 抗体

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. 再加上,我们可以发TMC8 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
TMC8 147138 Q8IU68
TMC8 688276  
TMC8 217356 Q7TN58
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antibodies-online.cn销售最多的anti-TMC8 抗体

Showing 10 out of 66 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB WB Suggested Anti-TMC8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: 721_B cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human tonsil, using TMC8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 WB TMC8 Antibody (N-term) (ABIN658164) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the TMC8 antibody detected the TMC8 protein (arrow). 400 μL Log in to see 10至11个工作日
$335.50
详细
非结合性 IHC, IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7至9个工作日
$484.00
详细
非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 IHC, ELISA, WB   100 μg Log in to see 15至19个工作日
$523.71
详细
非结合性 ELISA, WB   100 μg Log in to see 15至19个工作日
$523.71
详细
非结合性 ELISA, ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: EVER2 Antibody [NBP1-76903] - Human Brain cells. Western Blot: EVER2 Antibody [NBP1-76903] - Jurkat cell lysate with EVER2 antibody at (A) 1 and (B) 2 ug/ml. 0.1 mg Log in to see 8至11个工作日
$485.88
详细
非结合性 ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
详细

通过反应活性、应用领域、克隆类型和共轭标记 TMC8 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-TMC8 抗体

  1. Human Polyclonal TMC8 Primary Antibody for IHC, ELISA - ABIN1002274 : Ramoz, Taïeb, Rueda, Montoya, Bouadjar, Favre, Orth: Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25. in The Journal of investigative dermatology 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal TMC8 Primary Antibody for ELISA, WB - ABIN1002275 : Ramoz, Rueda, Bouadjar, Montoya, Orth, Favre: Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. in Nature genetics 2002 (PubMed)
    Show all 3 Pubmed References

更多抗TMC8的相互作用对抗体

Human Transmembrane Channel-Like 8 (TMC8) interaction partners

  1. The relatively high proportion of EV patients without mutation in TMC6 (显示 TMC6 抗体)/8 indicates the existence of EV-causing mutations in additional, presently unknown gene(s). However, a homozygous TMC8 splice site mutation in our patients resulted in aberrant transcripts which cannot retain the healthy phenotype

  2. The present study did not show any significant association of the EVER1 (显示 TMC6 抗体)/2 polymorphisms (rs2290907and rs16970849) with cervical cancer.

  3. There were no differences in Ever2 SNPs between head and neck squamous cell carcinoma patients with human papilloma virus (HPV)-positive and HPV-negative tumors, and healthy controls.

  4. Findings suggest that SNPs in EVER2 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC (显示 CYP11A1 抗体) tumours that have lost beta-HPV gene expression during progression.

  5. TMC6/EVER1 (显示 TMC6 抗体) and TMC8/EVER2 are known to be involved in the development of EV.

  6. A common genetic variation in TMC8 is associated with high-risk HPV infection and head and neck squamous cell carcinoma etiology.

  7. We found a possible correlation between the EVER2 TT genotype and the development of AK, suggesting a potential role of this polymorphism in the development of AK.

  8. EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 (显示 TMC6 抗体) or EVER2.

  9. TMC8 was found to be localized in the endoplasmic reticulum (ER), where it inhibited receptor mediated Ca(2 (显示 CA2 抗体)+) release, activation of Ano1 (显示 ANO1 抗体) and volume regulated LRRC8 (显示 LRRC8A 抗体)-related Cl(-) currents.

  10. Expression of both EVER1 (显示 TMC6 抗体) and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB (显示 NFKB1 抗体) signaling.

TMC8 抗原简介

蛋白简介

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.

Gene names and symbols associated with TMC8

  • transmembrane channel like 8 (TMC8) 抗体
  • transmembrane channel-like 8 (Tmc8) 抗体
  • transmembrane channel-like gene family 8 (Tmc8) 抗体
  • EV2 抗体
  • Ever2 抗体
  • EVIN2 抗体
  • mFLJ00400 抗体

Protein level used designations for TMC8

transmembrane channel-like 8 , FLJ00400 protein-like , transmembrane channel-like protein 8-like , epidermodysplasia verruciformis 2 , epidermodysplasia verruciformis protein 2 , transmembrane channel-like protein 8 , uncharacterized protein LOC688276 , epidermodysplasia verruciformis protein 2 homolog

GENE ID SPECIES
483342 Canis lupus familiaris
513813 Bos taurus
100031099 Monodelphis domestica
100443950 Pongo abelii
100478575 Ailuropoda melanoleuca
100596943 Nomascus leucogenys
100615612 Pan troglodytes
147138 Homo sapiens
688276 Rattus norvegicus
217356 Mus musculus
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