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TBXA2R encodes a member of the G protein-coupled receptor family. 再加上，我们可以发Thromboxane A2 Receptor 试剂盒 (23) 和 Thromboxane A2 Receptor 蛋白 (4)和数多这个蛋白质的别的产品。
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Thromboxane A2 receptor is expressed in both vagal and spinal neurons. Thromboxane A(2) may elicit stronger vagal or parasympathetic reflexes in the rabbit when released during tissue trauma depending on the location of release.
Data suggest that in hypoxic pulmonary hypertension, loss of site-specific phosphorylation of TBXA2R results in agonist hyper-responsiveness; Ser324 appears to be primary residue phosphorylated during protein kinase A activation of TBXA2R.
The study of patients with naturally occurring variants within TBXA2R associated with bleeding and abnormal TPalpha (显示 HADHA 抗体) receptor function has provided a powerful insight in defining the critical role of TPalpha (显示 HADHA 抗体) in thrombus formation.
these data demonstrate that TPalpha (显示 HADHA 抗体)/TPbeta can act as neoplastic and epigenetic regulators by mimicking and/or enhancing the actions of androgens within the prostate and provides further mechanistic insights into the role of the TXA2/TP signalling axis in prostate cancer, including potentially in CRPC.
Data show that thromboxane A2 receptor beta-isoform (TPbeta) is highly expressed in intrauterine growth restriction (IUGR) placentae but is absent from healthy placentae.
We conclude that hyperglycemia activates thromboxane A2 receptor to impair the integrity and function of blood-brain barrier via the ROCK-PTEN-Akt (显示 AKT1 抗体)-eNOS (显示 NOS3 抗体) pathway.
data presented herein propose a novel diagnostic and prognostic potential for TPalpha (显示 HADHA 抗体) and TPbeta in the histopathological assessment of PCa (显示 FLVCR1 抗体). While TPalpha (显示 HADHA 抗体) and TPbeta are differentially expressed and independently regulated, increased levels of TPbeta, TPalpha (显示 HADHA 抗体) or both correlated with increased risk of recurrence and reduced disease-free survival time.
TBXA2R is a novel breast cancer-associated (显示 ARID4B 抗体) gene required for the survival and migratory behaviour of a subset of Triple Negative Breast Cancer (TNBC).
TXA2R rs1131882TT genotype is associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients.
We demonstrate that Trp334 in the TPbeta C-terminus is critical for the CCT7 (显示 CCT7 抗体) interaction and plays an important role in TPbeta maturation and cell-surface expression.
TBXA2R +924C/T polymorphism is associated with asthma risk
A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 (显示 TBC1D9 抗体) C3435T, TBXA2R (rs1131882), and PLA2G7 (显示 Lp-PLA2 抗体) (rs1051931-rs7756935) polymorphisms.
The results suggest that EP3 (显示 PTGER3 抗体) along with TP contributes to vasoconstrictor responses evoked by PGI2 (显示 PTGIR 抗体), and hence imply a novel mechanism for endothelial cyclooxygenase metabolites (which consist mainly of PGI2 (显示 PTGIR 抗体)) in regulating vascular functions.
platelet GP6 (显示 GP6 抗体) and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation
Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation.
PKCalpha (显示 PKCa 抗体) deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression.
Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism.
Blocking the expression of the thromboxane receptor significantly suppresses the prothrombotic effect of C-reactive protein (显示 CRP 抗体).
The thromboxane A(2) receptor agonist 11-deoxy PGF (显示 PTGFR 抗体)(2alpha) can partially alleviate embryo crowding in the Lpar3 (显示 LPAR3 抗体)((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3 (显示 LPAR3 抗体)((-/-)) females.
We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow.
thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury
Thromboxane A2 receptor activation via PKC-zeta (显示 PRKCZ 抗体)-mediated NAD(P)H (显示 NQO1 抗体) oxidase activation increases superoxide and peroxynitrite, resulting in eNOS (显示 NOS3 抗体) uncoupling in endothelial cells.
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene.
thromboxane A2 receptor
, prostanoid TP receptor
, TXA2 receptor
, thromboxane prostanoid
, Thromboxane receptor