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Required for normal progression of S-phase. 再加上，我们可以发TIPIN 抗体 (71) 和 TIPIN 蛋白 (10)和数多这个蛋白质的别的产品。
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Mta2 (显示 MTA2 ELISA试剂盒) and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.
data indicate that Tipin/Tim1/And1 (显示 WDHD1 ELISA试剂盒) form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion
the 1.85 A crystal structure of a large N-terminal segment of human Timeless, spanning amino acids 1-463, is presented and this region of human Timeless harbours a partial binding site for Tipin.
TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer.
Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer (显示 MERTK ELISA试剂盒) DNA ligand.
Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins.
We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle.
RPA (显示 RPA1 ELISA试剂盒)-covered ssDNA not only supports recruitment and activation of ATR (显示 ANTXR1 ELISA试剂盒) but also, through Tipin and Claspin (显示 CLSPN ELISA试剂盒), it plays an important role in the action of ATR (显示 ANTXR1 ELISA试剂盒) on its critical downstream target Chk1 (显示 CHEK1 ELISA试剂盒)
The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks.
Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin (显示 CLSPN ELISA试剂盒) in response to replication checkpoint
observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless-depleted cells
TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.
mTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes
The tim-Tipin dysfunction creates an indispensible reliance on the ATR (显示 ATR ELISA试剂盒)-Chk1 (显示 CHEK1 ELISA试剂盒) pathway for continued DNA synthesis.
Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be required in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).
timeless interacting protein
, TIMELESS interacting protein
, timeless-interacting protein
, TIMELESS-interacting protein
, CSM3 homolog
, mitotic phosphoprotein 67