TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1) ELISA试剂盒

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. 再加上,我们可以发TBC1D1 抗体 (62)TBC1D1 蛋白 (5)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
TBC1D1 23216 Q86TI0
大鼠 TBC1D1 TBC1D1 360937  
TBC1D1 57915  
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小鼠 9.37 pg/mL 37.5-2400 pg/mL Typical standard curve 96 Tests Log in to see 15至18个工作日
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Pig (Porcine) TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1) interaction partners

  1. the TBC1D1 gene has an effect on meat, carcass and production traits in Italian heavy pigs.

Human TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1) interaction partners

  1. TBC1D1-Ser(231) phosphorylation and/or 14-3-3 binding partially mediates AMPK-governed glucose homeostasis and muscle glucose uptake in a context-dependent manner.

  2. data demonstrate heterozygous deactivating TBC1D1 mutations in CAKUT patients with a similar renal and ureteral phenotype, and provide evidence that TBC1D1 mutations may contribute to CAKUT

  3. AS160 and TBC1D1 phosphorylations were evident 30 min after exercise.

  4. Data show that TBC1D1 is expressed and phosphorylated in response to glucose in these cells.

  5. Moderate association of rs9852 indicates an influence of TBC1D1 for antipsychotic-induced weight gain.

  6. R125W mutation occurs in a location of the TBC1D1 PTB domain that is predicted to have a function in a putative protein:protein interaction.

  7. Data suggest that insulin increases phosphorylation of signaling nexus TBC1D1 independent of prior exercise or lipid/Intralipid administration.

  8. TBC1D1 is Ser237 phosphorylated and binding capacity to 14-3-3 protein is increased in skeletal muscle following exercise.

  9. [review] The question of a mechanism for increased phosphorylation of Ser237-TBC1D1 after exercise has, so far, not had a straightforward experimental approach for a direct answer in humans undergoing in vivo exercise.

  10. A single bout of exercise regulates TBC1D1 and AS160 phosphorylation on multiple sites in human skeletal muscle.

  11. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.

  12. coding variant R125W affects obesity susceptibility, delimits the location of an obesity gene at 4q34-35 and identifies a gene/gene interaction that influences the risk for obesity predisposition

  13. form of Tbc1d1 also inhibited GLUT4 translocation and that this effect also required a functional GAP domain

  14. These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition.

Mouse (Murine) TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1) interaction partners

  1. Isolated pancreatic islets from D1KO mice exhibited substantially increased glucose-stimulated insulin secretion compared with controls.TBC1D1 exerts its function via a signaling pathway at the level of membrane depolarization. In line, ultrastructural analysis of isolated pancreatic islets revealed both higher insulin-granule density and number of docked granules in beta-cells from D1KO mice compared with WT controls.

  2. in obese leptin-deficient mice, lack of TBC1D1 has no impact on feeding behavior or energy intake but results in increased energy expenditure, altered energy substrate preference with increased fatty acid oxidation and suppression of obesity; TBC1D1 may have an evolutionary conserved role in regulating energy homeostasis in vertebrates

  3. These findings demonstrate that the AMPK-TBC1D1 signaling nexus interacts with the PKB-mTOR pathway via IGF1 secretion, which consequently controls expression of lipogenic genes in the adipose tissue

  4. Rab28 is a substrate for the GAP domains of both TBC1D1 and TBC1D4 in vitro.

  5. Tbc1d1 knockout mice have GLUT4 expression and glucose uptake defects in skeletal muscle and adipose tissue. These defects combine in AS160 KO/Tbc1d1 KO mice, supporting nonredundant functions for AS160 and Tbc1d1.

  6. Data (including data from mice with Tbc1d1 gene deletion) suggest Tbc1d1 controls basal intracellular GLUT4 retention in large skeletal muscles; in small muscles (extensor digitorum longus) Tbc1d1 does not regulate basal GLUT4 cell surface exposure.

  7. Findings indicate that the RabGAP TBC1D1 plays a key role in regulating GLUT4 protein levels and in exercise-mediated glucose uptake in nonoxidative muscle fibers.

  8. TBC1D1-mediated reduction of muscle fatty acid oxidation appears to occur via inhibition of beta-hydroxyaacyl-CoA dehydrogenase activity.

  9. Data from knockout mice suggest that Tbc1d1 is involved in regulation of energy substrate metabolism (glucose vs. lipids) and energy homeostasis; Tbc1d1 plays important role in susceptibility to diabetes type 2, obesity, and hypertriglyceridemia.

  10. Tbc1d1 serves as a key regulator of aminoimidazole carboxamide ribonucleotide-induced GLUT4 liberation

  11. It was shown that TBC1D1 plays a role in regulation of glucose metabolism in skeletal muscle. Moreover, functional TBC1D1 was required for AICA ribonucleotide- or contraction-induced metabolic responses.

  12. Leptin enhances the intracellular GLUT4 transport in skeletal muscle of ob/ob animals by reducing the expression and activity of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4.

  13. TBC1D1 Ser237 phosphorylation in skeletal muscle is regulated by alpha2 5AMP-activated protein kinase.

  14. [review] Knockout mice have been used to probe the specific roles of AMP kinase isoforms in contraction-induced Ser237-Tbc1d1 phosphorylation.

  15. show that Tbc1d1, a gene known to mediate leanness and linked to obesity, is down-regulated in the absence of TDP-43

  16. Contraction causes site-specific phosphorylation of TBC1D1 in skeletal muscle.

  17. Amino acid substution of TBC1D1 impairs skeletal muscle glucose transport, which could be a mechanism for the obesity associated with this mutation.

  18. form of Tbc1d1 also inhibited GLUT4 translocation and that this effect also required a functional GAP domain

  19. TBC1D1 may be involved in controlling GLUT1 glucose transporter expression through the mTOR-p70 S6 kinase pathway

  20. Tbc1d1 is a component in the signal transduction pathway leading to AMPK-stimulated GLUT4 translocation in muscle.

TBC1D1 抗原简介

Antigen Summary

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6\; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000

Gene names and symbols associated with TBC1D1

  • TBC1 domain family member 1 (TBC1D1) 抗体
  • TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (tbc1d1) 抗体
  • TBC1 domain family member 1 (LOC100523386) 抗体
  • TBC1 domain family member 1 (tbc1d1) 抗体
  • TBC1 domain family member 1 (Tbc1d1) 抗体
  • TBC1 domain family, member 1 (Tbc1d1) 抗体
  • 1110062G02Rik 抗体
  • AI385682 抗体
  • AW555803 抗体
  • mKIAA1108 抗体
  • TBC 抗体
  • Tbc1 抗体
  • TBC1D1 抗体

Protein level used designations for TBC1D1

TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 , TBC1 domain family member 1-like , TBC1 domain family member 1 , lyncein , TBC1 domain family, member 1 , tre-2/USP6, BUB2, cdc16) domain family, member 1

GENE ID SPECIES
461163 Pan troglodytes
479115 Canis lupus familiaris
561193 Danio rerio
697357 Macaca mulatta
100022584 Monodelphis domestica
100055336 Equus caballus
100082442 Ornithorhynchus anatinus
100352741 Oryctolagus cuniculus
100453546 Pongo abelii
100523386 Sus scrofa
100556335 Anolis carolinensis
100601007 Nomascus leucogenys
23216 Homo sapiens
426162 Gallus gallus
282704 Bos taurus
360937 Rattus norvegicus
57915 Mus musculus
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