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Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. 再加上，我们可以发TIAM1 蛋白 (4)和数多这个蛋白质的别的产品。
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Human Polyclonal TIAM1 Primary Antibody for WB - ABIN1881884
Yang, Lv, Liu, Liu, Yang, Hu: Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma. in Japanese journal of clinical oncology 2010
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Human Polyclonal TIAM1 Primary Antibody for WB - ABIN250682
Redell, Zhao, Dash: Altered expression of miRNA-21 and its targets in the hippocampus after traumatic brain injury. in Journal of neuroscience research 2010
Findings indicate the role of Tiam1-Rac1-Nox2 (显示 CYBB 抗体) signaling pathway in the onset of spontaneous diabetes in the type 1 diabetes NOD mouse model.
Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades.
S1466 of Tiam1 is a novel Cdk1 (显示 CDK1 抗体) site whose phosphorylation is required for Tiam1's mitotic function.
endometrial Tiam1/Rac1 signal down-regulation along with miR (显示 MLXIP 抗体)-22 up-regulation during embryo implantation window in the natural menstrual cycle may be one of the reasons for the failure of embryo implantation in patients with repeated implantation failure
The MAP1B (显示 MAP1B 抗体)-Tiam1-Rac1 relay is essential for spine structural plasticity and removal of AMPA (显示 GRIA3 抗体) receptors from synapses during long-term depression.
Tiam1 is a regulator of the dopaminergic neurons development acting in the Wnt/Dvl/Rac1 pathway.
Tiam1, a specific activator of the small GTPase (显示 RACGAP1 抗体) Rac (显示 AKT1 抗体), is required for the polarized outgrowth of protrusions in primary astrocytes during the initial phase of cell polarization after scratch-wounding monolayers of cells.
Embryonic Tiam-1 expression plays a critical role during early brain development in mice.
Study shows that the NR2C (显示 GRIN2C 抗体) and Tiam1 maturation genes are synergistically controlled by the activity-dependent induction of Etv1 (显示 ETV1 抗体).
These findings demonstrate a novel Shh pathway that regulates the actin cytoskeleton via Tiam1-Rac1 activation.
the Ser179Glu mutant of SDC-4 (显示 SDC4 抗体) binds strongly Tiam1, a Rac1-GEF (显示 SLC2A4RG 抗体) reducing Rac1-GTP (显示 AK3 抗体) by 3-fold in MCF-7 breast adenocarcinoma cells.
results highlight the role of the PHn-CC-Ex domain in Tiam1 GEF regulation and suggest a combinatorial model for GEF inhibition and activation of the Rac1 signaling pathway.
Tiam1 expression is frequently up-regulated in breast cancer. Tiam1 expression correlated with clinicopathological parameters.
In colorectal carcinoma TIAM1 suppresses tumor progression by regulating YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) activity.
The expression of TIAM1 is closely related to the occurrence, development and metastasis of oral squamous cell carcinoma , and it can be used as a new marker for reflecting its biological behaviors.
TIAM1 was aberrantly expressed in the oral squamous cell carcinoma group compared with the normal group. Furthermore, high expression of TIAM1 was significantly correlated with lymph node metastasis and the timing of recurrence.
These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells.
we have identified a novel reverse signaling pathway acting through Tiam1 and Rac (显示 AKT1 抗体) that promotes aggressive behavior in OSCC expressing S4D and PB1 (显示 SMR3A 抗体).
Taken together, these results suggest that the Par3 (显示 F2RL2 抗体) regulates invasion and metastasis in pancreatic cancers by controlling tight junction assembly via Tiam1.
Tiam1 expression significantly increased in cholangiocarcinoma tissues, and increased along with the degree of malignancy of cholangiocarcinoma. Targeted silencing Tiam1 expression could inhibit proliferation and migration activity of cholangiocarcinoma cells.
G protein betagamma subunits, Src kinase (显示 CSK 抗体) and the GEF (显示 SLC2A4RG 抗体) Tiam1 are upstream modulators of S1P (显示 MBTPS1 抗体)-mediated Rac1 activation, and Rac1 has a role in S1P (显示 MBTPS1 抗体)-mediated activation of PI 3 (显示 PI3 抗体)-kinase/Akt (显示 AKT1 抗体)/endothelial nitric-oxide synthase (显示 NOS3 抗体) signaling in vascular endothelial cells
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
T-cell lymphoma invasion and metastasis 1
, T-lymphoma invasion and metastasis-inducing protein 1
, T-lymphoma invasion and metastasis-inducing protein 1-like
, t-lymphoma invasion and metastasis-inducing protein 1-like
, human T-lymphoma invasion and metastasis inducing TIAM1 protein