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The protein encoded by SYTL2 is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family.
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Our findings indicate that Slp2-a controls renal cell size through regulation of Rap (显示 LRPAP1 抗体)-ezrin (显示 EZR 抗体) signaling independently of Rab27 (显示 RAB27A 抗体).
Slp2-a is required for targeting of the signaling molecule podocalyxin (显示 PODXL 抗体) to the apical membrane in a Rab27A (显示 RAB27A 抗体)-dependent manner.
Calmodulin suppresses synaptotagmin-2 (显示 SYT2 抗体) transcription in cortical neurons
Loss of Slp2-a protein also induced a change in melanocyte morphology, from their normal elongated shape to a more rounded shape, which depended on the phospholipid-binding activity of Slp2-a
Slp2-a is part of the mucin (显示 SLC13A2 抗体) secretory machinery in surface mucous cells of mouse stomach
These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
The structural characterization of the Rab27a (显示 RAB27A 抗体)-exophilin4/Slp2-a complex will clarify Rab27 (显示 RAB27A 抗体) recognition by its effectors prior to vesicle tethering and docking.
The observed structural complementation between the interacting surfaces of Rab27a (显示 RAB27A 抗体) and Exophilin4 sheds light on the disparities among the Rab27 (显示 RAB27A 抗体) effectors and outlines a general mechanism for their recruitment.[exophilin4]
Syt2 (显示 SYT2 抗体) can serve as an exocytic sensor for diverse Ca(2 (显示 CA2 抗体)+) signaling systems, and its levels are limiting for stimulated secretory function in airway goblet cells
Stress-induced mitochondrial hyperfusion (SIMH) is independent of MFN2, BAX/BAK, and prohibitins, but requires L-OPA1, MFN1, and the mitochondrial inner membrane protein SLP-2.
Overexpression of SYTL2 promoted metastatic potential.
SLP2 may play an important role in tumorigenesis of esophageal squamous cell carcinoma.
A high expression level of SLP-2 may be associating with the development of invasion and metastasis in laryngeal squamous cell carcinoma and breast cancer.
Exophilin4/Slp2-a is specifically expressed in pancreatic alpha cells.
Rab27a (显示 RAB27A 抗体) recruits Slp2a-hem on vesicular structures in peripheral CTLs and following CTL-target (显示 CTH 抗体) cell conjugate formation, the Slp2a-hem/Rab27a (显示 RAB27A 抗体) complex colocalizes with perforin (显示 PRF1 抗体)-containing granules at the immunologic synapse
Rab27A (显示 RAB27A 抗体)/Slp2a expression in limb girdle muscular dystrophy 2B muscle provides a compensatory vesicular trafficking pathway that is able to repair membrane damage in the absence of dysferlin (显示 DYSF 抗体).
Synaptotagmin-like protein 2-a (Slp2-a) contains an N-terminal Slp (显示 SEPT9 抗体) homology domain (SHD (显示 SHD 抗体)) (PMID: 11327731). The SHD (显示 SHD 抗体) of Slp2-a specifically and directly binds the GTP (显示 AK3 抗体)-bound form of Rab27A (显示 RAB27A 抗体).
The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, synaptotagmin-like protein 2
, breast cancer-associated antigen SGA-72M
, chromosome 11 synaptotagmin