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SDHC encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria.
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Human Monoclonal SDHC Primary Antibody for ELISA, WB - ABIN520106
Lemarie, Grimm: Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells. in Mitochondrion 2009
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Studies indicate that the Tet-mev-1 conditional transgenic system can induce mutated SDHC gene in complex II.
SDHC Promoter hypermethylation is associated with Parasympathetic Paragangliomas.
SDH (显示 SARDH 抗体)-deficient gastrointestinal stromal tumors (GISTs) account for approximately 8% of gastric GISTs and are associated with a high rate of distant metastasis, regardless of conventional risk category.
31% of the paragangliomas in the French Canadian can be explained by the SDHC mutation (c.397C>T, p.[Arg133Ter]).
For classification, tumors were characterized by SDHA (显示 SDHA 抗体), B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline
Heterozygous germline deletions of up to 104 kb in size were identified in SDHB (显示 SDHB 抗体), SDHC, SDHD (显示 SDHD 抗体) and flanking genes in 20 paraganglioma-pheochromocytoma patients. The exact breakpoint could be determined in 16 paraganglioma-pheochromocytoma patients of which 15 were novel deletions
According to international guidelines, SDHB (显示 SDHB 抗体), SDHC, and SDHD (显示 SDHD 抗体) genetic testing were performed in this patient, but not SDHA (显示 SDHA 抗体), which would have been prescribed only after surgery, in case of SDHA (显示 SDHA 抗体) negative immunohistochemistry
Loss of the SDHC gene is associated with metastatic sympathetic paraganglioma.
This report provides evidence that SDHC promoter methylation can cause Paragangliomas due to SDHC inactivation
significant association with overall survival were confirmed for SDHC gene, SDHD (显示 SDHD 抗体) gene and FH gene ... SDHC gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma
This study strengthens the etiological association of SDH (显示 SARDH 抗体) genes with pituitary neoplasia, renal tumorigenesis, and gastric gastrointestinal stromal tumors. Also, pancreatic neuroendocrine tumor falls within the SDH (显示 SARDH 抗体)-related tumor spectrum.
This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described.
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
, ENSANGP00000017418-like protein
, OXPHOS complex II cytochrome B560 subunit
, succinate dehydrogenase C
, succinate dehydrogenase cytochrome b560 subunit, mitochondrial
, integral membrane protein CII-3
, succinate dehydrogenase complex, subunit C
, cytochrome B large subunit of complex II
, integral membrane protein CII-3b
, succinate dehydrgenase cytochrome b
, succinate dehydrogenase 3, integral membrane subunit
, succinate-ubiquinone oxidoreductase cytochrome B large subunit
, succinate dehydrogenase complex subunit C