anti-Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1 (SMCHD1) 抗体

SMCHD1 encodes a protein which contains a hinge region domain found in members of the SMC (structural maintenance of chromosomes) protein family. 再加上,我们可以发SMCHD1 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SMCHD1 74355 Q6P5D8
SMCHD1 23347 A6NHR9
SMCHD1    
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antibodies-online.cn销售最多的anti-SMCHD1 抗体

Showing 10 out of 17 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ICC, IF, IHC, IHC (p), SimWes, WB Immunohistochemistry-Paraffin: SMCHD1 Antibody [NBP1-82978] - Staining of human testis shows strong nuclear positivity in cells of seminiferus ducts. Simple Western: SMCHD1 Antibody [NBP1-82978] - Simple Western lane view shows a specific band for SMCHD1 in 0.2 mg/ml of U-251MG lysate. This experiment was performed under reducing conditions using the 66-440 kDa separation system. 0.1 mL Log in to see 10至13个工作日
$491.63
详细
小鼠 非结合性 IHC (p) Immunohistochemistry-Paraffin: SMCHD1 Antibody  - Staining of human endometrium shows nuclear immunoreactivity in glandular cells. Immunohistochemistry-Paraffin: SMCHD1 Antibody  - Staining of human stomach shows nuclear immunoreactivity in glandular cells. 100 μL Log in to see 10至13个工作日
$491.63
详细
非结合性 IC, IF, WB Immunofluorescent analysis of SMCHD1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Western blot analysis of SMCHD1 expression in SKOV3 (A), Jurkat (B), HepG2 (C), rat brain (D) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
非结合性 IF/ICC, WB Western blot analysis of extracts of various cell lines, using SMCHD1 antibody (ABIN5974343) at 1/1000 dilution. Immunofluorescence analysis of MCF-7 cells using SMCHD1 antibody (ABIN5974343). Blue: DAPI for nuclear staining. 100 μL Log in to see 11至16个工作日
$426.40
详细
非结合性 IF, WB Western blot analysis of extracts of various cell lines, using SMCHD1 antibody. Immunofluorescence analysis of MCF-7 cells using SMCHD1 antibody. 120 μL Log in to see 12至14个工作日
$251.90
详细
非结合性 IF, IHC, WB Western blot analysis of extracts of various cell lines, using SMCHD1 antibody. Immunofluorescence analysis of MCF7 cell using SMCHD1 antibody. Blue: DAPI for nuclear staining. 100 μL Log in to see 16 Days
$334.02
详细
非结合性 IF, IHC, WB   50 μL Log in to see 7至9个工作日
$361.17
详细
非结合性 IF/ICC, WB 100 μL Log in to see 11至18个工作日
$369.55
详细
非结合性 ICC, IF, IHC, IHC (p), IP, WB Western Blot: SMCHD1 Antibody [NBP1-49968] - Detection of Human SmcHD1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-SmcHD1 antibody used for WB at 0.04 mcg/ml (A) and 0.4 mcg/ml (B) and used for IP at 3 mcg/mg lysate. SmcHD1 was also immunoprecipitated by rabbit anti-SmcHD1 antibody which recognizes a downstream epitope. For blotting immunoprecipitated SmcHD1 was used. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). 0.1 mL Log in to see 7至9个工作日
$556.31
详细
非结合性 IHC, IP, WB Western Blot: SMCHD1 Antibody [NBP1-49969] - Detection of Human SmcHD1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-SmcHD1 antibody used for WB at 0.04 mcg/ml (A) and 0.4 mcg/ml (B) and used for IP at 3 mcg/mg lysate. SmcHD1 was also immunoprecipitated by rabbit anti-SmcHD1 antibody which recognizes an upstream epitope. For blotting immunoprecipitated SmcHD1 was used. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 3 seconds (B). 0.1 mL Log in to see 7至9个工作日
$556.31
详细

通过反应活性、应用领域、克隆类型和共轭标记 SMCHD1 抗体

特性 应用范围 宿主 克隆类型
Mouse (Murine)


Human ,
,
,
Rat (Rattus)


引用最多的anti-SMCHD1 抗体

  1. Human Polyclonal SMCHD1 Primary Antibody for ICC, IF - ABIN4354780 : Lemmers, Tawil, Petek, Balog, Block, Santen, Amell, van der Vliet, Almomani, Straasheijm, Krom, Klooster, Sun, den Dunnen, Helmer, Donlin-Smith, Padberg, van Engelen, de Greef, Aartsma-Rus, Frants et al.: Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2. ... in Nature genetics 2012 (PubMed)

更多抗SMCHD1的相互作用对抗体

Mouse (Murine) Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1 (SMCHD1) interaction partners

  1. This study demonstrated that the hinge domain of Smchd1 probably adopts an unconventional homodimeric arrangement augmented by an intermolecular coiled coil formed between the two monomers.

  2. An indirect interaction mediated by the LRIF1 (显示 C1orf103 抗体) and HP1 (显示 CBX5 抗体) proteins loads SMCHD1 onto chromatin marked by trimethylation of histone H3 (显示 HIST3H3 抗体) lysine 9 (H3K9me3).

  3. Data suggest that structural maintenance of chromosomes flexible hinge domain containing 1 (Smchd1) imparts epigenetic regulation via physical association with chromatin.

  4. SmcHD1 is an important regulator of imprinted and clustered genes

  5. Genome-wide expression analysis showed that Smchd1 is required for the silencing of around 10% of the genes on the inactive X chromosome, apparently independent of CpG island hypomethylation, and, moreover, that these genes nonrandomly occur in clusters.

  6. Smchd1-dependent CGI methylation, the primary pathway, is acquired gradually over an extended period, whereas Smchd1-independent CGI methylation occurs rapidly after the onset of X inactivation

  7. Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1 (显示 DNMT1 抗体), Dnmt3L (显示 TRDMT1 抗体), SmcHD1 and Foxo3a (显示 FOXO3 抗体) has no detectable effect on mouse telomere length in vivo.

  8. SmcHD1 is not required for correct Xist expression, but localizes to the inactive X and has a role in the maintenance of X inactivation and the hypermethylation of CpG islands associated with the inactive X.

Human Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1 (SMCHD1) interaction partners

  1. We discuss the involvement of this rearrangement in Facioscapulohumeral dystrophy (FSHD), since all mutations in SMCHD1 are not associated with D4Z4 hypomethylation and do not always segregate with the disease

  2. SMCHD1 acts as a repressor on a limited set of autosomal gene clusters, as an observed reduction in methylation associates with a loss of SMCHD1 binding and increased expression for some of the loci.

  3. We summarise here current understanding of the mechanism of action of SMCHD1, its role in these diseases, and what has been learnt from study of mouse models null for Smchd1 in the decade since the discovery of SMCHD1

  4. Mutations in SMCHD1 thus contribute to distinct phenotypic spectra.

  5. SMCHD1 as a key player in nasal development.

  6. SMCHD1 mutations cause Bosma arhinia microphthalmia syndrome.

  7. Study identified novel SMCHD1 mutations in a Japanese cohort of facioscapulohumeral muscular dystrophy 2 patients, confirming the presence of this disease in a wider population than previously known

  8. This study demonstrated that the the linkage peak revealed a variant (rs574972) within an intron of the gene SMCHD1 is linkaged to major depression in Mexican Americans.

  9. The synergistic effect has been demonstrated of two SMCHD1 variants on D4Z4 hypomethylation site and disease penetrance in facioscapulohumeral muscular dystrophy-2 patients.

  10. In the case of FSHD1, a contraction of the D4Z4 repeat array is disease causing whereas FSHD2 is most often caused by mutations in the structural maintenance of chromosomes hinge domain 1 (SMCHD1) gene.

SMCHD1 抗原简介

蛋白简介

This gene encodes a protein which contains a hinge region domain found in members of the SMC (structural maintenance of chromosomes) protein family.

Gene names and symbols associated with SMCHD1

  • SMC hinge domain containing 1 (Smchd1) 抗体
  • structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) 抗体
  • 4931400A14Rik 抗体
  • AW554188 抗体
  • mKIAA0650 抗体
  • MommeD1 抗体

Protein level used designations for SMCHD1

structural maintenance of chromosomes flexible hinge domain-containing protein 1 , SMC hinge domain-containing protein 1

GENE ID SPECIES
74355 Mus musculus
23347 Homo sapiens
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