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Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination.
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Human Polyclonal SMC5 Primary Antibody for IP, WB - ABIN151916
Draskovic, Arnoult, Steiner, Bacchetti, Lomonte, Londoño-Vallejo: Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination. in Proceedings of the National Academy of Sciences of the United States of America 2009
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Cow (Bovine) Polyclonal SMC5 Primary Antibody for ELISA - ABIN4244758
Pebernard, Perry, Tainer, Boddy: Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. in Molecular biology of the cell 2008
The SMC5/6 complex promotes sister chromatid cohesion after DNA breakage and facilitates homologous recombination between sister chromatids.
SMC5/6 knockdown rescued HBx-deficient hepatitis b virus replication in human hepatocytes.
High SMC5 protein is associated with hepatitis B.
The SMC5/6 complex physically interacts with the DNA topoisomerase II alpha (TOP2A (显示 TOP2A 抗体)).
results uncover a novel role for the Smc5/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression
Structural maintenance of chromosomes (SMC (显示 DYM 抗体)) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics
Depletion of Smc5 and Smc6 (显示 SMC6 抗体) resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors
Studies indicate that Nse1 (显示 FAM84A 抗体) may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex.
the human SMC5/6 complex and the SUMO ligase activity of hMMS21 (显示 NSMCE2 抗体) are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells
SMC5/6 complex is recruited to nuclease-induced double-strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs.
SMC5/6 complex facilitates telomere homologous recombination and elongation in alternative lengthening of telomeres cells through SUMOylation of telomere-binding proteins.
age-dependent depletion of the SMC5/6 complex in oocytes could contribute to increased incidence of oocyte aneuploidy and spontaneous abortion in aging females.
The Smc5/6 complex is regulated during the cell cycle, presumably in anticipation of DNA damage that may arise during replication.
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression\; the function seems to be independent of SMC6 (By similarity).
SMC protein 5
, structural maintenance of chromosomes protein 5
, SMC5 structural maintenance of chromosomes 5-like 1
, protein expressed in male leptotene and zygotene spermatocytes 453