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STAG1 is a member of the SCC3 family and is expressed in the nucleus. 再加上，我们可以发Stromal Antigen 1 蛋白 (3)和数多这个蛋白质的别的产品。
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Human Polyclonal Stromal Antigen 1 Primary Antibody for ICC, IF - ABIN151764
Zhang, Kuznetsov, Sharan, Li, Rao, Pati: A handcuff model for the cohesin complex. in The Journal of cell biology 2008
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Here the authors demonstrate that the most frequently mutated subunit of the cohesin complex (显示 SMC3 抗体), STAG2 (显示 STAG2 抗体), displays a strong synthetic lethal interaction with its paralog STAG1. Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 (显示 STAG2 抗体) mutated but not in wild-type cells leading to mitotic catastrophe, defective cell division and apoptosis.
This first series reporting the phenotype ascribed to mutation in STAG1 highlights the importance of data sharing in the field of rare disorders.
Data indicate that cohesin subunit SA-1 (STAG1) is a promising therapeutic target in cancers with inactivating alterations of cohesin subunit SA-2 (STAG2 (显示 STAG2 抗体)).
There is LOH at STAG1 and STAG2 loci in oral squamous cell carcinoma (OSCC), but OSCC and NM showed similar transcriptional levels of STAG1, STAG2, and PDS5B.
Data support the hypothesis that CTCF (显示 CTCF 抗体) and cohesin SA-1 have multiple roles in the regulation of gene expression during erythropoiesis.
TRF1 (显示 TERF1 抗体) tethers SA1 within telomeric regions that SA1 transiently interacts with. SA1 and TRF1 (显示 TERF1 抗体) together form longer DNA-DNA pairing tracts than with TRF1 (显示 TERF1 抗体) alone, as revealed by atomic force microscopy imaging
Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 (显示 STAG2 抗体) expressed in Saccharomyces cerevisiae.
Mutations in STAG1 is associated with acute myeloid leukemia (显示 BCL11A 抗体).
cohesin-SA1 and cohesin-SA2 (显示 STAG2 抗体) participate in the DNA damage response
Rad21 (显示 RAD21 抗体) binds to SA proteins through two SA-binding motifs on Rad21 (显示 RAD21 抗体).
reduced dosage of SA1 altered the architecture of the Reg (显示 KCNH2 抗体) locus and decreased the expression of Reg (显示 KCNH2 抗体) genes in the pancreas of SA1 heterozygous mice
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.
stromal antigen 1
, SCC3 homolog 1
, cohesin subunit SA-1
, nuclear protein stromal antigen 1
, cohesin subunit XSA1
, stromal antigen 1 homolog