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Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro.
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We conclude that upon ligand binding, TLR4 (显示 TLR4 抗体) activates PI3K/Akt (显示 AKT1 抗体) signaling to induce F-spondin expression, subsequently control CREB (显示 CREB1 抗体)-mediated IL-6 (显示 IL6 抗体) production to promote VSMC migration. These findings provide vital insights into the essential role of F-spondin in VSMC function and will be valuable for developing new therapeutic strategies against atherosclerosis.
These findings demonstrated novel roles for F-spondin and IL-1Ra (显示 IL1RN 抗体) in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages.
Spon1 deletion leads to a local and systemic reduction of TGF-beta levels resulting in increased BMP signaling and increased bone deposition in adult mice.
F-spondin is expressed in embryonic cartilage, where it has the capacity to enhance chondrocyte terminal differentiation and mineralization.
gene expression experiment revealed that CYP2B6 (显示 CYP2B6 抗体), SPON1, and GSG1L can be activated concomitantly through a constitutive androstane receptor (显示 NR1I3 抗体) (CAR) activation pathway
SPON1 promotes metastatic progression through Fak (显示 PTK2 抗体) and Src (显示 SRC 抗体) dependent pathway in human osteosarcoma.
These data suggest that SPON1 may be associated with the differential rate of cognitive decline in Alzheimer disease.
High SPON1 expression is associated with high-grade gliomas.
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity
downregulates osteoclast recruitment to the root side of periodontal tissue via low-density lipoprotein receptor-related protein 8 (显示 LRP8 抗体) and inhibits differentiation of osteoclastic precursors
These findings indicate that F-spondin regulates the differentiation of human cementoblast-like cells via BMP7 (显示 BMP7 抗体) expression.
The unique feature of F-spondin FS domain is the presence of three disulfide bonds associated with the N- and C-termini of the domain and a highly conserved N-linked glycosylation site.
expression profile of VSGP/F-spondin identifies this molecule as a potential diagnostic marker or target for developing therapeutic strategies to treat ovarian carcinoma
identified F-spondin as a promoting factor for cementoblastic differentiation
the porcine testis produces F-spondin and production of this protein is evident in the immature porcine testis, but not the adult testis.
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity).
, spondin 1, (f-spondin) extracellular matrix protein
, vascular smooth muscle cell growth-promoting factor