anti-Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) 抗体

SF3B4 encodes one of four subunits of the splicing factor 3B.

列出全部抗体 基因 基因ID UniProt
小鼠 SF3B4 SF3B4 107701 Q8QZY9
大鼠 SF3B4 SF3B4 295270 Q6AYL5
 SF3B4 SF3B4 10262 Q15427
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antibodies-online.cn销售最多的anti-Splicing Factor 3b, Subunit 4, 49kDa 抗体

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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-SF3B4 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Jurkat cell lysate SF3B4 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 IHC, WB WB Suggested Anti-SF3B4 Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate SF3B4 is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit Anti-SF3B4 Antibody  Paraffin Embedded Tissue: Human Intestine Cellular Data: Epithelial cells of intestinal villas Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL Log in to see 2至3个工作日
$229.00
详细
山羊 非结合性 ELISA, WB ABIN184797 staining (0.1µg/ml) of Hela lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6至7个工作日
$358.02
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Cow 山羊 非结合性 WB   0.1 mg Log in to see 8至11个工作日
$462.00
详细
非结合性 ICC, IF, WB WB Image Sample (30 ug of whole cell lysate) A: Hela 10% SDS PAGE antibody diluted at 1:1000 WB Image Sample (30 ug of whole cell lysate) A: NIH-3T3 B: JC 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1至2个工作日
$358.60
详细
Bat 非结合性 IHC, IHC (p), WB 100 μg Log in to see 7至9个工作日
$493.17
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Bat 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
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Bat 山羊 非结合性 ELISA, WB 100 μg Log in to see 7至9个工作日
$610.50
详细
非结合性 ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
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非结合性 IHC, WB   200 μL Log in to see 13至14个工作日
$487.50
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引用最多的anti-Splicing Factor 3b, Subunit 4, 49kDa 抗体

  1. Human Polyclonal SF3B4 Primary Antibody for WB - ABIN1881796 : Watanabe, Shionyu, Kimura, Kimata, Watanabe: Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation. in The Journal of biological chemistry 2007 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal SF3B4 Primary Antibody for ELISA, WB - ABIN249606 : Champion-Arnaud, Reed: The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. in Genes & development 1994 (PubMed)

更多抗Splicing Factor 3b, Subunit 4, 49kDa的相互作用对抗体

Xenopus laevis Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) interaction partners

  1. Sf3b4-depleted embryos show reduced expression of the neural crest genes sox10 (显示 SOX10 抗体), snail2 and twist at the neural plate border, associated with a broadening of the neural plate. This phenotype can be rescued by injection of wild-type human SF3B4 mRNA but not by mRNAs carrying mutations that cause Nager syndrome.

Human Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) interaction partners

  1. We identified two heterozygous frameshift mutations in the SF3B4 gene in three of the four fetuses investigated. The observed mutation was apparently de novo in one fetus for whom parental DNA was available. Thus, Acrofacial dysostosis syndrome of Rodriguez is an autosomal dominant condition and the recurrences identified in the initial report were likely due to gonadal mosaicism.

  2. A novel synonymous variant within exon 3 of the SF3B4 gene was identified in three members of a family affected by Nager syndrome.

  3. Chemical shift mapping showed that the SF3b145 (显示 SF3B2 抗体) fragment spanning residues 598-631 interacts with SF3b49 RRM1 (显示 RRM1 抗体), which adopts a canonical RRM fold with a topology of beta1-alpha1-beta2-beta3-alpha2-beta4.

  4. SF3B4 mutations identified in Rodriguez Acrofacial Dysostosis patients disrupted mRNA splicing and reduced expression of DLX5, DLX6, SOX9, and SOX6 in cultured chondrocytes.

  5. splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 (显示 STAT3 抗体) signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 (显示 STAT3 抗体) on a tyrosine residue at position 705.

  6. Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC (显示 FAM126A 抗体)

  7. High SF3B4 expression is associated with hepatocellular carcinoma.

  8. SF3B4 haploinsufficiency confirmed as the major cause of Nager syndrome.

  9. SF3B4 mutation is associated with Nager syndrome.

  10. These results suggest that most cases of Nager syndrome are caused by haploinsufficiency of SF3B4.

Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) 抗原简介

蛋白简介

This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.

Gene names and symbols associated with SF3B4

  • Splicing factor 3B subunit 4 (sap-49) 抗体
  • splicing factor 3b, subunit 4 (sf3b4) 抗体
  • splicing factor 3b, subunit 4 (Sf3b4) 抗体
  • splicing factor 3b subunit 4 S homeolog (sf3b4.S) 抗体
  • splicing factor 3b subunit 4 (SF3B4) 抗体
  • 49kDa 抗体
  • AFD1 抗体
  • chunp6902 抗体
  • fb36a04 抗体
  • Hsh49 抗体
  • SAP49 抗体
  • SF3b49 抗体
  • SF3b50 抗体
  • spx 抗体
  • wu:fb36a04 抗体

Protein level used designations for SF3B4

splicing factor 3B subunit 4 , splicing factor 3b, subunit 4, 49kD , spliceosome associated protein 49 , SAP 49 , SF3b50 , pre-mRNA-splicing factor SF3b 49 kDa subunit , spliceosomal protein , spliceosome-associated protein (U2 snRNP) , spliceosome-associated protein 49

GENE ID SPECIES
4363023 Caenorhabditis elegans
192318 Danio rerio
107701 Mus musculus
295270 Rattus norvegicus
379792 Xenopus laevis
10262 Homo sapiens
483177 Canis lupus familiaris
506123 Bos taurus
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