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SF3B2 encodes subunit 2 of the splicing factor 3b protein complex.
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Human Polyclonal SF3B2 Primary Antibody for ICC, IF - ABIN256719
Tresini, Warmerdam, Kolovos, Snijder, Vrouwe, Demmers, van IJcken, Grosveld, Medema, Hoeijmakers, Mullenders, Vermeulen, Marteijn: The core spliceosome as target and effector of non-canonical ATM signalling. in Nature 2015
Human Polyclonal SF3B2 Primary Antibody for ICC, IF - ABIN256720
Yang, Hadjikyriacou, Xia, Gayatri, Kim, Zurita-Lopez, Kelly, Guo, Li, Clarke, Bedford: PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. in Nature communications 2015
a docking model based on NOESY measurements suggests that residues 607-616 of the SF3b145 fragment adopt a helical structure that binds to RRM1 (显示 RRM1 抗体) predominantly via alpha1, consequently exhibiting a helix-helix interaction in almost antiparallel.
High SF3B2 expression is associated with hepatocellular carcinoma.
Although amino acid substitutions of residues surrounding Arg-508 had no great effect on PRMT9 (显示 FBXO11 抗体) recognition of SF3B2, moving the arginine residue within this sequence abolished methylation.
Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6 (显示 EIF6 抗体)) and hnRNA splicing (SF3B2/SF3B4 (显示 SF3B4 抗体)), showed that human T cells can enter the cell cycle without growing in size.
Data show that Vpr induces checkpoint activation and G(2) arrest by binding to the CUS1 domain of SAP145 and interfering with the functions of the SAP145 and SAP49 (显示 SF3B4 抗体) proteins, two subunits of the multimeric splicing factor 3b (显示 SF3B14 抗体) (SF3b).
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.
splicing factor 3B subunit 2
, splicing factor 3b, subunit 2, 145kDa
, splicing factor 3B subunit 2-like
, SAP 145
, pre-mRNA splicing factor SF3b 145 kDa subunit
, pre-mRNA-splicing factor SF3b 145 kDa subunit
, spliceosome associated protein 145
, spliceosome-associated protein 145