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May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity).. 再加上，我们可以发Spindlin 1 抗体 (42) 和 Spindlin 1 蛋白 (9)和数多这个蛋白质的别的产品。
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Spin1 is essential to maintain metaphase II stage arrest, but a high level of Spin1 induces DNA damage in oocytes and embryos.
we describe the first example of a histone code reader controlling SkM development in mice, which hints at Spin1 as a potential player in human SkM disease.
miR (显示 MLXIP ELISA试剂盒)-489 loss facilitates malignant phenotype of glioma cells probably via SPIN1-mediated PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒) pathway.
In triple negative breast cancer (TNBC) cells the simultaneous miR (显示 MLXIP ELISA试剂盒)-29b-1-5p down regulation and SPIN1 up-regulation can potentially be associated with TNBC malignancy.
These data indicate that miR (显示 MLXIP ELISA试剂盒)-489 could reverse the chemoresistance of breast cancer via the PI3K (显示 PIK3CA ELISA试剂盒)-Akt (显示 AKT1 ELISA试剂盒) pathway by targeting SPIN1.
High SPIN1 expression is associated with liposarcoma.
Spindlin1 activates Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling downstream from protein arginine methyltransferase 2 (PRMT2 (显示 PRMT2 ELISA试剂盒)) and the MLL complex, which together are capable of generating a specific H3 "K4me3-R8me2a" pattern.
the histone sequence is recognized in a distinct manner involving the amino terminus and a pair of arginine residues of histone H3 (显示 HIST3H3 ELISA试剂盒), and disruption of the binding impaired stimulation of pre-RNA expression by Spindlin1
SPINDLIN1, which may be a novel substrate of the Aurora-A kinase (显示 AURKA ELISA试剂盒), promotes cancer cell growth through WNT (显示 WNT2 ELISA试剂盒)/TCF-4 (显示 TCF4 ELISA试剂盒) signaling activation.
Spin1 regulates maternal transcripts post-transcriptionally and is involved in meiotic resumption
Spin1 isoform2 is a protein expressed highly in adult testis, which might be involved in spermatogenesis and could be necessary for normal sperm motility
May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity).
ovarian cancer-related protein
, 30000 Mr metaphase complex
, SSEC P
, spindlin 1