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In complex with CUL3, involved in ubiquitination and proteasomal degradation of several substrates (By similarity). 再加上，我们可以发SPOP-B 抗体 (72) 和 SPOP-B 试剂盒 (28)和数多这个蛋白质的别的产品。
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Expression of the F133V mutation and wild-type SPOP was at much lower levels compared to that of F102C and Y87N mutations; however, at present, it is unknown if this also affects the biological activity of the SPOP protein.
PD-L1 protein abundance is regulated by cyclin D-CDK4 and the cullin 3-SPOP E3 ligase via proteasome-mediated degradation
methylation status of SPOP promoter can be used as a novel epigenetic biomarker and a therapeutic target in colorectal cancer.
these data highlight SPOP as an important regulator of luminal epithelial cell proliferation and c-MYC expression in prostate physiology, identify c-MYC as a novel bona fide SPOP substrate, and help explain the frequent inactivation of SPOP in human prostate adenocarcinoma.
Results elucidate the tumor-suppressor role of SPOP in prostate cancer in which it acts as a negative regulator of BET protein stability and also provide a molecular mechanism for resistance to BET inhibitors in individuals with prostate cancer bearing SPOP mutations.
SPOP mutation in endometrial cancer increased degradation of BRD2 (显示 BRD2 蛋白), BRD3 (显示 BRD3 蛋白) and BRD4 (显示 BRD4 蛋白) proteins. SPOP mutation in prostate cancer increased expression of BRD2 (显示 BRD2 蛋白), BRD3 (显示 BRD3 蛋白) and BRD4 (显示 BRD4 蛋白) proteins.
Prostate cancer-derived SPOP mutants failed to interact with Cdc20 (显示 CDC20 蛋白) to promote its degradation. As a result, SPOP-deficient prostate cancer cells with elevated Cdc20 (显示 CDC20 蛋白) expression became resistant to a pharmacological Cdc20 (显示 CDC20 蛋白) inhibitor.
While wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a diffuse distribution in the nucleus. SPOP oligomerizes through its BTB and BACK domains.
SPOP mutation activates both PI3K (显示 PIK3CA 蛋白)/mTOR (显示 FRAP1 蛋白) and androgen receptor (显示 AR 蛋白) signaling, effectively uncoupling the normal negative feedback between these two pathways.
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.
loss of Spop, but not Spopl (显示 SPOPL 蛋白), disrupts chondrocyte hypertrophy and osteoblast differentiation in the mouse, suggesting the requirement for Spop-mediated protein degradation in mouse skeletal development; overexpressed Spop targets both Gli3FL (显示 GLI3 蛋白) and Gli3R for ubiquitination and degradation and Spop is an important positive regulator of Ihh (显示 IHH 蛋白) signaling and skeletal development
Results demonstrate a negative role of Spop in the level and activity of Gli3 (显示 GLI3 蛋白), Shh (显示 SHH 蛋白) signaling and ventral spinal cord patterning.
Speckle-type pox virus and zinc finger (POZ) protein (SPOP) regulates endometrial stromal cell decidualization in mice and that hormones regulate the expression of SPOP. This study suggests that ubiquitination may be involved in embryonic implantation.
These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.
miR-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.
Dzip1 (显示 DZIP1 蛋白)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (显示 GLI1 蛋白)/Ci proteins in the Hh pathway.
similar S/T-rich motifs are present in Gli proteins as well as in numerous HIB-interacting proteins and mediate Gli degradation by SPOP
MacroH2A1.2 binds the nuclear protein Spop.
Interaction of endogenous PDX-1 (显示 PDX1 蛋白) and PCIF1 in MIN6 insulinoma (显示 RPS15 蛋白) cells, is demonstarted.
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
HIB homolog 1
, roadkill homolog 1
, PDX-1 C-terminal-interacting factor 1
, speckle-type POZ protein B