Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 蛋白 (SLC8A3)

SLC8A3 encodes a member of the sodium/calcium exchanger integral membrane protein family. 再加上,我们可以发Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 抗体 (56)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
SLC8A3 6547 P57103
大鼠 SLC8A3 SLC8A3 140448 P70549
SLC8A3 110893  
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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SLC8A3 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
, ,
Mouse (Murine)
,

更多Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 (SLC8A3)互动伙伴

Human Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 (SLC8A3) interaction partners

  1. These results...suggest that cells can use a dynamic Ca(2 (显示 CA2 蛋白)+) signaling toolkit in which the NCX3 sub-cellular localization changes in synchrony with the cell cycle

  2. Structure-Dynamic Coupling Through Ca(2 (显示 CA2 蛋白)+)-Binding Regulatory Domains of Mammalian NCX (显示 TLX2 蛋白) Isoform/Splice Variants

  3. stimulation of NCX3 by PKA occurred through residue S524. This effect may well participate in the fight-or-flight response in skeletal muscle and the long-term potentiation in hippocampus.

  4. In the discovery phase, 60 loci not previously associated with rheumatoid arthritis risk showed evidence for association and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level. When combining the discovery and validation cohorts, an intronic SNP in SLC8A3 was found to be associated with ACPA (显示 PRTN3 蛋白)-positive rheumatoid arthritis at a genome-wide level of significance.

  5. Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain.

  6. NCX1 (显示 SLC8A1 蛋白) and NCX3 -represent two promising druggable targets for setting on new strategies in stroke therapy.

  7. NCX (显示 TLX2 蛋白) isoforms (NCX2, NCX3) contribute to mitochondrial Na(+)/Ca(2 (显示 CA2 蛋白)+) exchange in human DAergic neurons and may act downstream of PINK1 (显示 PINK1 蛋白) in the prevention of neurodegeneration by m[Ca(2 (显示 CA2 蛋白)+)] accumulation.

  8. the large cytosolic loop of NCX1 (显示 SLC8A1 蛋白), NCX2, and NCX3 is involved in acquisition of immunosuppressive drug specificity

  9. Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 and NCX3, but not NCX2, were divergently modulated during OPC differentiation into oligodendrocyte.

  10. human macrophages and monocytes express NCX1 (显示 SLC8A1 蛋白) and NCX3 that operate in a bidirectional manner to restore [Ca(2 (显示 CA2 蛋白)+)](i) to generate Ca(2 (显示 CA2 蛋白)+) signals and to induce TNF-alpha (显示 TNF 蛋白) production.

Mouse (Murine) Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 (SLC8A3) interaction partners

  1. This study demonstrate that knocking-out NCX3 impairs oligodendrocyte response and worsens clinical symptoms in EAE without altering the immune T-cell population.

  2. Demonstrate that NCX3 genetic deletion protects against ziram-induced neurotoxicity and suggest NCX3 and its downstream molecular pathways as key factors involved in ziram toxicity.

  3. NCX3 regulates mitochondrial calcium handling from the outer mitochondrial membrane through an AKAP121 (显示 AKAP1 蛋白)-anchored signaling complex.

  4. Function and regulation of the Na+-Ca2+ exchanger (显示 SLC8A1 蛋白) NCX3 splice variants in brain and skeletal muscle.

  5. the use of genetic-modified mice for NCX1 (显示 SLC8A1 蛋白), NCX2, and NCX3 represents a fruitful strategy to characterize the physiological role exerted by NCX (显示 SLC8A1 蛋白) in CNS

  6. Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 and NCX3, but not NCX2, were divergently modulated during OPC differentiation into oligodendrocyte.

  7. the solution structure of NCX3 calcium binding domain 2B

  8. calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation.

  9. Results show that glucocorticoid treatment blunts LPS (显示 TLR4 蛋白)-induced increase in [Ca(2 (显示 CA2 蛋白)+)](i) in dendritic cells by increasing expression and activity of Na(+)/Ca(2 (显示 CA2 蛋白)+) exchanger NCX3.

  10. The deletion of the NCX3 gene has detrimental consequences on basal synaptic transmission, long term potentiation regulation, spatial learning, and memory performance.

蛋白简介Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 (SLC8A3)

蛋白简介

This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described.

Gene names and symbols associated with SLC8A3

  • solute carrier family 8 member A3 (SLC8A3)
  • solute carrier family 8 (sodium/calcium exchanger), member 3 (SLC8A3)
  • solute carrier family 8 (sodium/calcium exchanger), member 3 (slc8a3)
  • solute carrier family 8 member A3 (Slc8a3)
  • solute carrier family 8 (sodium/calcium exchanger), member 3 (Slc8a3)
  • AW742262 蛋白
  • Ncx3 蛋白
  • SLC8A3 蛋白

Protein level used designations for SLC8A3

solute carrier family 8 (sodium-calcium exchanger), member 3 , solute carrier family 8 member 3 , solute carrier family 8 (sodium/calcium exchanger), member 3 , sodium/calcium exchanger 3-like , Na(+)/Ca(2+)-exchange protein 3 , Na+/Ca2+ exchanger 3 , sodium/calcium exchanger 3 , sodium/calcium exchanger SLC8A3 , sodium-calcium exchanger

GENE ID SPECIES
467491 Pan troglodytes
490755 Canis lupus familiaris
100034161 Equus caballus
100152101 Sus scrofa
100339605 Oryctolagus cuniculus
100412630 Callithrix jacchus
100471755 Ailuropoda melanoleuca
100487508 Xenopus (Silurana) tropicalis
100541915 Meleagris gallopavo
100603298 Nomascus leucogenys
6547 Homo sapiens
140448 Rattus norvegicus
540307 Bos taurus
110893 Mus musculus
395759 Gallus gallus
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