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may transport glucose out of the rough endoplasmic reticulum into the cytosol in response to glucose administration; may play a role in glucose homeostasis in hippocampal neurons.
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Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction
these data suggest that cytoplasmic trehalose access is carrier-mediated, and that GLUT8 is a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction.
glucose/fructose is transported into the cytoplasm of vimentin (显示 VIM ELISA试剂盒)- or GFAP (显示 GFAP ELISA试剂盒)-positive astrocytic and CD68 (显示 CD68 ELISA试剂盒)- or HLA-DR-positive microglial cells located around the lateral ventricle
GLUT8 is thus essential for hepatocyte fructose transport and fructose-induced macrosteatosis.
SLC2A8 is upregulated in fast progressing Alzheimer's disease patients, compared to slow progressors.
Critical roles for novel GLUT (显示 SLC2A1 ELISA试剂盒) family members highlight a therapeutic strategy entailing selective GLUT (显示 SLC2A1 ELISA试剂盒) inhibition to specifically target aberrant glucose metabolism in cancer.
The recruitment of GLUT8 to the endocytic machinery occurs via direct interaction of the dileucine motif with beta2-adaptin (显示 AP2B1 ELISA试剂盒), and that endocytosis might be the main site at which GLUT8 is likely to be regulated.
The expression pattern of GLUT8 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry.
Insulin (显示 INS ELISA试剂盒)-stimulated translocation of GLUT4 (显示 SLC2A4 ELISA试剂盒) and GLUT8 was down-regulated in the atria of insulin (显示 INS ELISA试剂盒) resistance animals, as well as their total protein expression.
Neonatal hypothyroridism downregulates the expressions of GLUT3 (显示 SLC2A3 ELISA试剂盒) and GLUT8 in the testis of perpubertal mice.
GLUT-4 (显示 SLC2A4 ELISA试剂盒) and -8 are insulin (显示 INS ELISA试剂盒)-sensitive.
Resistance to high-fructose diet-induced glucose intolerance and dyslipidemia concomitant with enhanced oxygen consumption and thermogenesis in GLUT8-deficient male mice.
Intestinal dehydroascorbic acid (DHA) transport is mediated by the facilitative sugar transporters, GLUT2 (显示 SLC2A2 ELISA试剂盒) and GLUT8
Ovarian transplantation studies confirm that lack of SLC2A8 affects both the embryo and the implantation processes. This phenotype leads to decreased litter size, and smaller pups at weaning.
Report GLUT8 expression in normal left ventricle and in models of dilated and hypertophic cardiomyopathy.
Data conclude that GLUT8 regulates enterocyte fructose transport by regulating GLUT12, and that disrupted GLUT8 function has deleterious long-term metabolic sequelae.
This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene.
glucose transporter 8
, glucose transporter type 8
, glucose transporter type X1
, solute carrier family 2, facilitated glucose transporter member 8
, solute carrier family 2, (facilitated glucose transporter) member 8
, glucose transporter X1
, intestinal GLUT8 transporter